Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPR84 | Q9NQS5 | 4/20 | 0.62 |
| ▸ | MEN1 | O00255 | 2/20 | 0.62 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.62 |
| ▸ | AHR | P35869 | 2/20 | 0.62 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.62 |
| ▸ | MAPT | P10636 | 1/20 | 0.62 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.62 |
| ▸ | IDO1 | P14902 | 1/20 | 0.48 |
| ▸ | HTR6 | P50406 | 2/20 | 0.47 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.46 |
| ▸ | GOT1 | P17174 | 1/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.44 |
| ▸ | HTR1A | P08908 | 2/20 | 0.44 |
| ▸ | HTR2A | P28223 | 2/20 | 0.44 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.44 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.44 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.44 |
| ▸ | HTR1D | P28221 | 1/20 | 0.44 |
| ▸ | HTR1B | P28222 | 1/20 | 0.44 |
| ▸ | HTR2C | P28335 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27946629 | 0.80 | IDO1 (0.70) | GPR84MEN1KMT2AAHRCYP3A4 | |
| Arundine SCHEMBL325162 | 0.79 | MEN1 (1.00) | GPR84MEN1KMT2AAHRCYP3A4 | |
| SCHEMBL28658592 | 0.77 | SLC22A6 (0.50) | GPR84MEN1KMT2AAHRCYP3A4 | |
| SCHEMBL31744605 | 0.77 | MEN1 (0.68) | GPR84MEN1KMT2AAHRCYP3A4 | |
| Arundine SCHEMBL28335217 | 0.77 | MEN1 (0.95) | GPR84MEN1KMT2AAHRCYP3A4 | |
| SCHEMBL1856636 | 0.74 | MEN1 (0.58) | GPR84MEN1KMT2AAHRCYP3A4 | |
| SCHEMBL27704617 | 0.74 | GPR84 (0.53) | GPR84CYP3A4MAPTSMN1; SMN2ALDH1A1 | |
| SCHEMBL29007187 | 0.72 | GPR84 (1.00) | GPR84MEN1KMT2AAHRCYP3A4 | |
| SCHEMBL23144846 | 0.71 | MEN1 (0.75) | GPR84MEN1KMT2AAHRCYP3A4 | |
| SCHEMBL3132443 | 0.71 | MEN1 (0.75) | GPR84MEN1KMT2AAHRCYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1322646-A1 | 2-(1H-INDOL-3-YL)-2-OXO-ACETIC ACID AMIDES WITH ANTITUMOR ACTIVITY | Novuspharma S.p.A. (IT) | 2003-07-02 | — | — | EP | disclosed |
| WO-2002008225-A1 | 2-(1H-INDOL-3-YL)-2-OXO-ACETIC ACID AMIDES WITH ANTITUMOR ACTIVITY | NOVUSPHARMA S.P.A. (IT) | 2002-01-31 | — | — | WO | disclosed |