Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 1/20 | 0.52 |
| ▸ | RAB9A | P51151 | 1/20 | 0.52 |
| ▸ | MLYCD | O95822 | 2/20 | 0.47 |
| ▸ | MAPT | P10636 | 10/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.46 |
| ▸ | TP53 | P04637 | 2/20 | 0.46 |
| ▸ | THRB | P10828 | 1/20 | 0.46 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.46 |
| ▸ | PANK3 | Q9H999 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.46 |
| ▸ | MEN1 | O00255 | 2/20 | 0.46 |
| ▸ | HPGD | P15428 | 1/20 | 0.44 |
| ▸ | HTT | P42858 | 1/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6285286 | 0.80 | MAPT (0.59) | NPC1RAB9AMAPTSMN1; SMN2ALDH1A1 | |
| SCHEMBL6286671 | 0.76 | TDP1 (0.41) | RAB9AMLYCDMAPTALDH1A1KMT2A | |
| SCHEMBL17669252 | 0.75 | MAPT (0.71) | NPC1RAB9AMAPTSMN1; SMN2ALDH1A1 | |
| SCHEMBL15801114 | 0.75 | MAPT (0.71) | NPC1RAB9AMAPTSMN1; SMN2ALDH1A1 | |
| SCHEMBL17483654 | 0.74 | ALDH1A1 (0.46) | RAB9AMAPTSMN1; SMN2ALDH1A1TP53 | |
| SCHEMBL12986356 | 0.73 | PRKDC (0.48) | NPC1RAB9AMAPTSMN1; SMN2TP53 | |
| SCHEMBL15341960 | 0.73 | HRH3 (0.44) | MAPTALDH1A1KDM4E | |
| SCHEMBL18878402 | 0.73 | ALDH1A1 (0.53) | NPC1RAB9AMAPTSMN1; SMN2ALDH1A1 | |
| SCHEMBL14417582 | 0.71 | MAPT (0.64) | NPC1RAB9AMAPTSMN1; SMN2ALDH1A1 | |
| SCHEMBL7956272 | 0.70 | NPC1 (0.69) | NPC1RAB9AMAPTSMN1; SMN2ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20030187040-A1 | 2-Ureido-thiazole derivatives, process for their preparation, and their use as antitumor agents | PHARMACIA & UPJOHN SPA (IT) | 2003-10-02 | — | — | US | claimed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20030187040-A1 | 2-Ureido-thiazole derivatives, process for their preparation, and their use as antitumor agents | UCK2, ULK3, CDK2 | NPC1 2685/4885RAB9A 2674/4885MLYCD 2725/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.