Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRIN1 | Q05586 | 1/20 | 0.36 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.36 |
| ▸ | POLB | P06746 | 3/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | HPGD | P15428 | 1/20 | 0.34 |
| ▸ | GRM5 | P41594 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
| ▸ | TP53 | P04637 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.33 |
| ▸ | GRM4 | Q14833 | 1/20 | 0.33 |
| ▸ | AGTR1 | P30556 | 1/20 | 0.33 |
| ▸ | THRB | P10828 | 1/20 | 0.33 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.33 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | PPP1CA | P62136 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6973271 | 0.93 | POLB (0.35) | POLBHPGDSMN1; SMN2TP53ALDH1A1 | |
| SCHEMBL8508399 | 0.92 | LMNA (0.36) | GRIN1GRIN2BPOLBLMNAGRM5 | |
| SCHEMBL7077261 | 0.90 | POLB (0.35) | POLBLMNAALDH1A1THRBKMT2A | |
| SCHEMBL6974276 | 0.90 | GRIN1 (0.37) | GRIN1GRIN2BALDH1A1GRM4ADORA2A | |
| SCHEMBL6961462 | 0.88 | GRIN1 (0.37) | GRIN1GRIN2BPOLBHPGDGRM5 | |
| SCHEMBL6969739 | 0.87 | POLB (0.38) | GRIN1GRIN2BPOLBHPGDTP53 | |
| SCHEMBL6972096 | 0.87 | LMNA (0.37) | POLBLMNASMN1; SMN2TP53ALDH1A1 | |
| SCHEMBL6974408 | 0.87 | L3MBTL1 (0.44) | POLBLMNASMN1; SMN2TP53ALDH1A1 | |
| SCHEMBL7085418 | 0.86 | POLB (0.38) | GRIN1GRIN2BPOLBHPGDTP53 | |
| SCHEMBL7080069 | 0.86 | S1PR3 (0.37) | GRIN1GRIN2BALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0786455-B1 | IMIDAZOLE DERIVATIVE | SHIONOGI & CO (JP) | 2003-12-03 | — | — | EP | disclosed |
| US-6147097-A | METHOD FOR TREATING AIDS | SHIONOGI & CO., LTD. (JP) | 2000-11-14 | — | — | US | disclosed |
| EP-0786455-A1 | IMIDAZOLE DERIVATIVE | SHIONOGI & CO., LTD. (JP) | 1997-07-30 | — | — | EP | disclosed |