Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 2/20 | 0.35 |
| ▸ | TLR7 | Q9NYK1 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | THRB | P10828 | 1/20 | 0.33 |
| ▸ | HPGD | P15428 | 1/20 | 0.33 |
| ▸ | ACHE | P22303 | 1/20 | 0.33 |
| ▸ | P2RX3 | P56373 | 1/20 | 0.33 |
| ▸ | TP53 | P04637 | 1/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.32 |
| ▸ | GAA | P10253 | 1/20 | 0.32 |
| ▸ | GRM4 | Q14833 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7086513 | 0.93 | GRIN1 (0.36) | POLBALDH1A1KMT2ATHRBHPGD | |
| SCHEMBL7077261 | 0.90 | POLB (0.35) | POLBTLR7ALDH1A1MEN1KMT2A | |
| SCHEMBL7080069 | 0.89 | S1PR3 (0.37) | TLR7ALDH1A1ACHE | |
| SCHEMBL6974447 | 0.88 | MEN1 (0.34) | TLR7ALDH1A1MEN1KMT2AP2RX3 | |
| SCHEMBL6973437 | 0.86 | MEN1 (0.40) | ALDH1A1MEN1KMT2AHPGDTP53 | |
| SCHEMBL6974276 | 0.86 | GRIN1 (0.37) | ALDH1A1KMT2AACHEGRM4 | |
| SCHEMBL6962934 | 0.86 | MEN1 (0.39) | ALDH1A1MEN1KMT2AHPGDTP53 | |
| SCHEMBL8508399 | 0.85 | LMNA (0.36) | POLBALDH1A1TP53SMN1; SMN2GRM4 | |
| SCHEMBL7081725 | 0.85 | TP53 (0.32) | POLBTLR7THRBTP53 | |
| SCHEMBL6975001 | 0.84 | ALDH1A1 (0.33) | TLR7ALDH1A1MEN1KMT2AP2RX3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0786455-B1 | IMIDAZOLE DERIVATIVE | SHIONOGI & CO (JP) | 2003-12-03 | — | — | EP | disclosed |
| US-6147097-A | METHOD FOR TREATING AIDS | SHIONOGI & CO., LTD. (JP) | 2000-11-14 | — | — | US | disclosed |
| US-5910506-A | IMIDAZOLE DERIVATIVES, E.G.5-(3,5-DICHLOROPHENYLTHIO)-1,2-DIMETHYL-4-ISOPROPYL-1H-IMIDAZOLE; VIRICIDES; AIDS; NONTOXIC | SHIONOGI & CO., LTD. (JP) | 1999-06-08 | — | — | US | disclosed |
| EP-0786455-A1 | IMIDAZOLE DERIVATIVE | SHIONOGI & CO., LTD. (JP) | 1997-07-30 | — | — | EP | disclosed |