Known targets — ChEMBL curated mechanism
ADRA2AADRA2BADRA2CADRB2AGTR1AVPR1AAVPR1BAVPR2BDKRB2CALCRCHRNA3CHRNB4ESR1ESR2GHSRGNRHRGSC1HSPA8MALT1MC1RMC4RNOS1NOS2NOS3OPRK1OXTRRAMP1RAMP2RAMP3SCN5ASSTR1SSTR2SSTR3SSTR4SSTR5dacAdacBdacCfolPftsImrcAmrcBmrdArplArplBrplCrplDrplErplFrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmFrpmGrpmHrpmIrpmJrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUykgMykgO
The experimentally established mechanism targets of Ascorbic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 2/20 | 0.73 |
| ▸ | LMNA | P02545 | 2/20 | 0.73 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.73 |
| ▸ | HSPD1 | P10809 | 1/20 | 0.48 |
| ▸ | HSPE1 | P61604 | 1/20 | 0.48 |
| ▸ | TST | Q16762 | 1/20 | 0.48 |
| ▸ | RECQL | P46063 | 1/20 | 0.48 |
| ▸ | BLM | P54132 | 1/20 | 0.48 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.48 |
| ▸ | TYR | P14679 | 2/20 | 0.40 |
| ▸ | MANBA | O00462 | 1/20 | 0.31 |
| ▸ | THRB | P10828 | 1/20 | 0.31 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Ascorbic Acid SCHEMBL408448 | 0.94 | MAPT (0.78) | MAPTLMNAL3MBTL1HSPD1HSPE1 | |
| Ascorbic Acid SCHEMBL165191 | 0.94 | MAPT (0.78) | MAPTLMNAL3MBTL1HSPD1HSPE1 | |
| Ascorbic Acid SCHEMBL31356983 | 0.91 | MAPT (0.83) | MAPTLMNAL3MBTL1HSPD1HSPE1 | |
| Ascorbic Acid SCHEMBL4087692 | 0.91 | MAPT (0.83) | MAPTLMNAL3MBTL1HSPD1HSPE1 | |
| Ascorbic Acid SCHEMBL28255170 | 0.91 | MAPT (0.83) | MAPTLMNAL3MBTL1HSPD1HSPE1 | |
| Ascorbic Acid SCHEMBL21372601 | 0.89 | MAPT (0.81) | MAPTLMNAL3MBTL1HSPD1HSPE1 | |
| Ascorbic Acid SCHEMBL21372605 | 0.89 | MAPT (0.81) | MAPTLMNAL3MBTL1HSPD1HSPE1 | |
| Ascorbic Acid SCHEMBL21372602 | 0.89 | LMNA (0.81) | MAPTLMNAL3MBTL1HSPD1HSPE1 | |
| Ascorbic Acid SCHEMBL15226289 | 0.89 | MAPT (0.86) | MAPTLMNAL3MBTL1HSPD1HSPE1 | |
| Ascorbic Acid SCHEMBL5968922 | 0.88 | MAPT (0.83) | MAPTLMNAL3MBTL1HSPD1HSPE1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2003072612-A1 | NITRO-DERIVATIVES OF LOW MOLECULAR WEIGHT HEPARIN | NICOX S.A. (FR) | 2003-09-04 | — | — | WO | disclosed |
| EP-1340771-A1 | Nitro-derivatives of low molecular weight heparin | Nicox S.A (FR) | 2003-09-03 | — | — | EP | disclosed |