Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2C | P28335 | 4/20 | 0.49 |
| ▸ | HTR2A | P28223 | 3/20 | 0.49 |
| ▸ | HTR2B | P41595 | 3/20 | 0.49 |
| ▸ | GAA | P10253 | 1/20 | 0.48 |
| ▸ | SMO | Q99835 | 1/20 | 0.47 |
| ▸ | SORT1 | Q99523 | 1/20 | 0.46 |
| ▸ | LRRK2 | Q5S007 | 3/20 | 0.45 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.44 |
| ▸ | SRPK3 | Q9UPE1 | 1/20 | 0.42 |
| ▸ | RAB9A | P51151 | 1/20 | 0.42 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6788361 | 0.89 | SMO (0.56) | HTR2CHTR2AHTR2BSMORAB9A | |
| SCHEMBL6794869 | 0.86 | SMO (0.56) | HTR2CHTR2AHTR2BSMORAB9A | |
| SCHEMBL7087226 | 0.85 | SMO (0.49) | SMOSORT1LRRK2SRPK3TRPV1 | |
| SCHEMBL6503248 | 0.85 | HTR2C (0.49) | HTR2CHTR2AHTR2BGAASMO | |
| SCHEMBL7080705 | 0.85 | SMO (0.49) | GAASMOSORT1LRRK2TRPV1 | |
| SCHEMBL6259089 | 0.84 | GAA (0.53) | GAALRRK2SRPK3RAB9A | |
| SCHEMBL6497088 | 0.81 | HTR2C (0.51) | HTR2CHTR2AHTR2BGAASMO | |
| SCHEMBL7083646 | 0.81 | GAA (0.49) | HTR2CHTR2AHTR2BGAALRRK2 | |
| SCHEMBL6924381 | 0.81 | GAA (0.45) | HTR2CHTR2AHTR2BGAALRRK2 | |
| SCHEMBL7084419 | 0.80 | MAPT (0.50) | SMOSORT1LRRK2RAB9ATRPV1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0676395-B1 | Substituted N-heteroaroylguanidines, as inhibitors of sodium-hydrogen exchange, as antiarrhythmic agents and as inhibitors of the proliferation of cells | HOECHST AG (DE) | 2003-09-03 | — | — | EP | disclosed |
| EP-1326835-A1 | BENZAMIDE COMPOUNDS AS APO B SECRETION INHIBITORS | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 2003-07-16 | — | — | EP | disclosed |
| WO-2002028835-A1 | BENZAMIDE COMPOUNDS AS APO B SECRETION INHIBITORS | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 2002-04-11 | — | — | WO | disclosed |