Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA | P10253 | 1/20 | 0.53 |
| ▸ | PTGDR2 | Q9Y5Y4 | 2/20 | 0.52 |
| ▸ | LRRK2 | Q5S007 | 3/20 | 0.48 |
| ▸ | RAB9A | P51151 | 2/20 | 0.46 |
| ▸ | NPC1 | O15118 | 2/20 | 0.44 |
| ▸ | MAPT | P10636 | 1/20 | 0.44 |
| ▸ | SRPK3 | Q9UPE1 | 1/20 | 0.44 |
| ▸ | TNF | P01375 | 1/20 | 0.44 |
| ▸ | NOD1 | Q9Y239 | 1/20 | 0.44 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6805247 | 0.89 | MTTP (0.49) | GAAPTGDR2RAB9ANPC1TNF | |
| SCHEMBL7086871 | 0.84 | HTR2C (0.49) | GAALRRK2RAB9ASRPK3 | |
| SCHEMBL7083646 | 0.83 | GAA (0.49) | GAALRRK2RAB9ANPC1MAPT | |
| SCHEMBL6924381 | 0.81 | GAA (0.45) | GAALRRK2RAB9ANPC1SRPK3 | |
| SCHEMBL7086631 | 0.77 | NPC1 (0.54) | RAB9ANPC1 | |
| SCHEMBL6256948 | 0.77 | CXCR1 (0.54) | GAARAB9ANPC1MAPTTNF | |
| SCHEMBL7133291 | 0.76 | NPC1 (0.56) | RAB9ANPC1 | |
| SCHEMBL6792746 | 0.76 | PTGS1 (0.57) | RAB9ANPC1 | |
| SCHEMBL7086952 | 0.76 | PLG (0.53) | LRRK2RAB9ANPC1 | |
| SCHEMBL7079790 | 0.76 | S1PR1 (0.51) | RAB9ANPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1578725-A1 | MICROSOMAL TRIGLYCERIDE TRANSFER PROTEIN INHIBITORS | Pfizer Products Inc. (US) | 2005-09-28 | — | — | EP | disclosed |
| WO-2004056777-A1 | MICROSOMAL TRIGLYCERIDE TRANSFER PROTEIN INHIBITORS | PFIZER PRODUCTS INC. (US) | 2004-07-08 | — | — | WO | disclosed |