Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 | P14416 | 13/20 | 0.56 |
| ▸ | DRD4 | P21917 | 12/20 | 0.56 |
| ▸ | DRD3 | P35462 | 12/20 | 0.56 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.51 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.51 |
| ▸ | CHRM2 | P08172 | 2/20 | 0.47 |
| ▸ | CHRM4 | P08173 | 2/20 | 0.47 |
| ▸ | CHRM5 | P08912 | 2/20 | 0.47 |
| ▸ | CHRM1 | P11229 | 2/20 | 0.47 |
| ▸ | CHRM3 | P20309 | 2/20 | 0.47 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.47 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.47 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.47 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.47 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.47 |
| ▸ | HTR1A | P08908 | 1/20 | 0.46 |
| ▸ | HTR2A | P28223 | 1/20 | 0.46 |
| ▸ | HTR7 | P34969 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7166882 | 0.89 | GRIN1 (0.52) | DRD2DRD4DRD3GRIN1GRIN2B | |
| SCHEMBL6965133 | 0.88 | DRD2 (0.62) | DRD2DRD4DRD3GRIN1GRIN2B | |
| Hydrochloric Acid SCHEMBL6959218 | 0.87 | DRD2 (0.61) | DRD2DRD4DRD3GRIN1GRIN2B | |
| SCHEMBL5498800 | 0.86 | DRD2 (0.59) | DRD2DRD4DRD3GRIN1GRIN2B | |
| Hydrochloric Acid SCHEMBL7168274 | 0.85 | DRD2 (0.58) | DRD2DRD4DRD3GRIN1GRIN2B | |
| SCHEMBL6964123 | 0.84 | HTR1A (0.51) | DRD2DRD4DRD3GRIN1GRIN2B | |
| SCHEMBL6966637 | 0.84 | DRD2 (0.49) | DRD2DRD4DRD3GRIN1GRIN2B | |
| Oxalic Acid SCHEMBL6959134 | 0.83 | DRD2 (0.53) | DRD2DRD4DRD3 | |
| SCHEMBL6966798 | 0.82 | DRD2 (0.54) | DRD2DRD4DRD3GRIN1GRIN2B | |
| Hydrochloric Acid SCHEMBL6973026 | 0.82 | DRD2 (0.53) | DRD2DRD4DRD3GRIN1GRIN2B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0934312-B1 | 1,4-DISUBSTITUTED PIPERAZINES | NOVO NORDISK AS (DK) | 2003-03-19 | — | — | EP | disclosed |
| US-6133268-A | 1,4-disubstituted piperazines | NOVO NORDISK A/S (DK) | 2000-10-17 | — | — | US | disclosed |
| US-6004961-A | ANTIINFLAMMATORY AGENTS, ANALGESICS; NON-INSULIN-DEPENDENT DIABETES; AGE-RELATED OBESITY; DIBENZO(D,G)(1,3,6)DIOXAZOCINE DERIVATIVES | NOVO NORDISK A/S (DK) | 1999-12-21 | — | — | US | disclosed |
| EP-0934312-A1 | 1,4-DISUBSTITUTED PIPERAZINES | NOVO NORDISK A/S (DK) | 1999-08-11 | — | — | EP | disclosed |
| WO-1998015548-A1 | 1,4-DISUBSTITUTED PIPERAZINES | NOVO NORDISK A/S (DK) | 1998-04-16 | — | — | WO | disclosed |