Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Oxalic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 | P14416 | 17/20 | 0.53 |
| ▸ | DRD4 | P21917 | 17/20 | 0.53 |
| ▸ | DRD3 | P35462 | 17/20 | 0.53 |
| ▸ | HRH1 | P35367 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7166882 | 0.90 | GRIN1 (0.52) | DRD2DRD4DRD3 | |
| SCHEMBL6966637 | 0.90 | DRD2 (0.49) | DRD2DRD4DRD3HRH1 | |
| SCHEMBL6966798 | 0.89 | DRD2 (0.54) | DRD2DRD4DRD3HRH1 | |
| Hydrochloric Acid SCHEMBL6973026 | 0.88 | DRD2 (0.53) | DRD2DRD4DRD3HRH1 | |
| SCHEMBL6964123 | 0.86 | HTR1A (0.51) | DRD2DRD4DRD3 | |
| SCHEMBL6971825 | 0.84 | DRD2 (0.51) | DRD2DRD4DRD3HRH1 | |
| SCHEMBL7087330 | 0.83 | DRD2 (0.56) | DRD2DRD4DRD3 | |
| SCHEMBL6965133 | 0.81 | DRD2 (0.62) | DRD2DRD4DRD3 | |
| Hydrochloric Acid SCHEMBL6959218 | 0.80 | DRD2 (0.61) | DRD2DRD4DRD3 | |
| SCHEMBL6957294 | 0.79 | OPRK1 (0.44) | DRD2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0934312-B1 | 1,4-DISUBSTITUTED PIPERAZINES | NOVO NORDISK AS (DK) | 2003-03-19 | — | — | EP | disclosed |
| US-6133268-A | 1,4-disubstituted piperazines | NOVO NORDISK A/S (DK) | 2000-10-17 | — | — | US | disclosed |
| US-6040302-A | ANTIINFLAMMATORY AGENTS TREATING RHEUMATOID ARTHRITIS, MIGRAINE OR ITCHING, INSULIN RESISTANCE IN NON-INSULIN-DEPENDENT DIABETES MELLITUS AND AGEING-ASSOCIATED OBESITY | NOVO NORDISK A/S (DK) | 2000-03-21 | — | — | US | disclosed |
| US-6004961-A | ANTIINFLAMMATORY AGENTS, ANALGESICS; NON-INSULIN-DEPENDENT DIABETES; AGE-RELATED OBESITY; DIBENZO(D,G)(1,3,6)DIOXAZOCINE DERIVATIVES | NOVO NORDISK A/S (DK) | 1999-12-21 | — | — | US | disclosed |
| EP-0934312-A1 | 1,4-DISUBSTITUTED PIPERAZINES | NOVO NORDISK A/S (DK) | 1999-08-11 | — | — | EP | disclosed |
| WO-1998015548-A1 | 1,4-DISUBSTITUTED PIPERAZINES | NOVO NORDISK A/S (DK) | 1998-04-16 | — | — | WO | disclosed |