Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CASR | P41180 | 4/20 | 0.47 |
| ▸ | CCR5 | P51681 | 3/20 | 0.45 |
| ▸ | CNR1 | P21554 | 1/20 | 0.44 |
| ▸ | CNR2 | P34972 | 1/20 | 0.44 |
| ▸ | LMNA | P02545 | 3/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.41 |
| ▸ | MAPT | P10636 | 3/20 | 0.41 |
| ▸ | HPGD | P15428 | 2/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | PKM | P14618 | 1/20 | 0.41 |
| ▸ | RECQL | P46063 | 1/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 3/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.40 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
| ▸ | TP53 | P04637 | 1/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4394376 | 0.86 | CCR5 (0.51) | CASRCCR5LMNAALDH1A1MAPT | |
| SCHEMBL4401960 | 0.82 | ALDH1A1 (0.47) | ALDH1A1POLBGAAMEN1KMT2A | |
| SCHEMBL4394593 | 0.81 | CASR (0.53) | CASRALDH1A1GAA | |
| Hydrochloric Acid SCHEMBL4391804 | 0.80 | CASR (0.53) | CASRALDH1A1GAA | |
| SCHEMBL4394677 | 0.79 | CASR (0.45) | CASRLMNAALDH1A1MAPTGAA | |
| SCHEMBL4399312 | 0.79 | CASR (0.42) | CASRCCR5CNR1LMNAGAA | |
| Hydrochloric Acid SCHEMBL4403194 | 0.78 | CASR (0.50) | CASRALDH1A1GAAMEN1KMT2A | |
| SCHEMBL4397200 | 0.77 | SIGMAR1 (0.39) | CNR1LMNAALDH1A1POLBGAA | |
| SCHEMBL4395802 | 0.77 | CASR (0.42) | CASRCCR5NPC1 | |
| Hydrochloric Acid SCHEMBL4397072 | 0.76 | CASR (0.41) | CASRCCR5LMNAALDH1A1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1358171-A2 | NOVEL UREA DERIVATIVES, METHOD FOR PREPARING SAME, USE THEREOF AS MEDICINES, PHARMACEUTICAL COMPOSITIONS AND NOVEL USE | Aventis Pharma S.A. (FR) | 2003-11-05 | — | — | EP | disclosed |
| WO-2002059102-A2 | UREA DERIVATIVES, METHOD FOR PREPARING SAME, USE THEREOF AS MEDICINES, PHARMACEUTICAL COMPOSITIONS AND USE | AVENTIS PHARMA S.A. (FR) | 2002-08-01 | — | — | WO | disclosed |