Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 3/20 | 0.51 |
| ▸ | TP53 | P04637 | 2/20 | 0.51 |
| ▸ | ADRA1D | P25100 | 2/20 | 0.46 |
| ▸ | SLC6A4 | P31645 | 4/20 | 0.44 |
| ▸ | DRD2 | P14416 | 1/20 | 0.44 |
| ▸ | GPR84 | Q9NQS5 | 1/20 | 0.40 |
| ▸ | HTR1A | P08908 | 1/20 | 0.40 |
| ▸ | TDO2 | P48775 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.39 |
| ▸ | HTR2A | P28223 | 1/20 | 0.39 |
| ▸ | JAK3 | P52333 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.39 |
| ▸ | GFER | P55789 | 1/20 | 0.39 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.39 |
| ▸ | TGFBR1 | P36897 | 1/20 | 0.39 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.39 |
| ▸ | BCHE | P06276 | 1/20 | 0.39 |
| ▸ | ACHE | P22303 | 1/20 | 0.39 |
| ▸ | ALKBH5 | Q6P6C2 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6816456 | 1.00 | MAPT (0.51) | MAPTTP53ADRA1DSLC6A4DRD2 | |
| SCHEMBL6492432 | 0.79 | MAPT (0.40) | MAPTTP53KDM4EJAK3KMT2A | |
| SCHEMBL30009870 | 0.76 | MAPT (0.55) | MAPTTP53KDM4EKMT2AGFER | |
| SCHEMBL6811811 | 0.76 | ADRA1D (0.49) | MAPTADRA1DSLC6A4DRD2GPR84 | |
| SCHEMBL23043645 | 0.73 | HTT (0.55) | MAPTTP53KDM4EKMT2AGFER | |
| SCHEMBL29978273 | 0.73 | HTT (0.55) | MAPTTP53KDM4EKMT2AGFER | |
| SCHEMBL6811813 | 0.67 | KDM4E (0.45) | MAPTTP53ADRA1DKDM4EKMT2A | |
| SCHEMBL16801555 | 0.66 | TP53 (0.52) | MAPTTP53HTR1ATDO2ALDH1A1 | |
| SCHEMBL18324734 | 0.66 | TDO2 (0.50) | HTR1ATDO2NPSR1ALDH1A1 | |
| SCHEMBL9983954 | 0.65 | GFER (0.63) | MAPTTP53KMT2AGFERALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1345930-A2 | PHARMACEUTICAL COMPOUNDS | ELI LILLY AND COMPANY (US) | 2003-09-24 | — | — | EP | disclosed |
| WO-2002050067-A2 | PHARMACEUTICAL HETEROCYCLIC COMPOUNDS | ELI LILLY AND COMPANY (US) | 2002-06-27 | — | — | WO | disclosed |