Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LTA4H | P09960 | 1/20 | 0.48 |
| ▸ | PLA2G2A | P14555 | 1/20 | 0.48 |
| ▸ | HTR2A | P28223 | 2/20 | 0.48 |
| ▸ | MEN1 | O00255 | 2/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.46 |
| ▸ | FAAH | O00519 | 1/20 | 0.46 |
| ▸ | HTR1A | P08908 | 11/20 | 0.46 |
| ▸ | HTR1B | P28222 | 10/20 | 0.46 |
| ▸ | HTR1D | P28221 | 8/20 | 0.46 |
| ▸ | MAPT | P10636 | 2/20 | 0.45 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.45 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.45 |
| ▸ | TP53 | P04637 | 1/20 | 0.45 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.45 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.45 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.45 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.45 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.45 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7082793 | 0.97 | LTA4H (0.48) | LTA4HPLA2G2AHTR2AMEN1KMT2A | |
| SCHEMBL7088534 | 0.96 | HTR1B (0.48) | LTA4HPLA2G2AHTR2AMEN1KMT2A | |
| SCHEMBL7084434 | 0.94 | LTA4H (0.50) | LTA4HPLA2G2AHTR2AMEN1KMT2A | |
| SCHEMBL7086847 | 0.85 | LTA4H (0.46) | LTA4HPLA2G2AHTR2AMEN1KMT2A | |
| SCHEMBL7090377 | 0.85 | HTR1A (0.54) | HTR2AMEN1KMT2AHTR1AHTR1B | |
| SCHEMBL7084248 | 0.82 | LTA4H (0.46) | LTA4HPLA2G2AHTR2AMEN1KMT2A | |
| SCHEMBL7089493 | 0.82 | LTA4H (0.51) | LTA4HPLA2G2AHTR2AMEN1KMT2A | |
| SCHEMBL7084332 | 0.81 | HTR1B (0.56) | HTR2AMEN1KMT2AHTR1AHTR1B | |
| SCHEMBL7087739 | 0.81 | HTR1A (0.46) | LTA4HPLA2G2AHTR2AMEN1KMT2A | |
| SCHEMBL7089721 | 0.81 | THRA (0.45) | LTA4HPLA2G2AHTR2AMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1268422-A1 | INDOLES FOR TREATING DISEASES THAT CAN BE TREATED USING THYROID HORMONES | Bayer Aktiengesellschaft (DE) | 2003-01-02 | — | — | EP | disclosed |
| WO-2001070687-A1 | INDOLES FOR TREATING DISEASES THAT CAN BE TREATED USING THYROID HORMONES | BAYER AKTIENGESELLSCHAFT (DE) | 2001-09-27 | — | — | WO | disclosed |