Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OXTR | P30559 | 5/20 | 0.57 |
| ▸ | AVPR1A | P37288 | 3/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 9/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.45 |
| ▸ | MAPT | P10636 | 6/20 | 0.45 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.45 |
| ▸ | TP53 | P04637 | 2/20 | 0.45 |
| ▸ | USP2 | O75604 | 1/20 | 0.45 |
| ▸ | FAAH | O00519 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.41 |
| ▸ | RAB9A | P51151 | 4/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.41 |
| ▸ | NPC1 | O15118 | 3/20 | 0.41 |
| ▸ | MEN1 | O00255 | 2/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.41 |
| ▸ | HPGD | P15428 | 5/20 | 0.40 |
| ▸ | TSHR | P16473 | 3/20 | 0.40 |
| ▸ | CASP1 | P29466 | 3/20 | 0.40 |
| ▸ | CASP7 | P55210 | 2/20 | 0.40 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4939037 | 1.00 | OXTR (0.57) | OXTRAVPR1AALDH1A1KDM4EMAPT | |
| SCHEMBL4939858 | 0.85 | OXTR (0.55) | OXTRAVPR1AALDH1A1MAPTSMN1; SMN2 | |
| SCHEMBL4944225 | 0.85 | ALDH1A1 (0.45) | OXTRAVPR1AALDH1A1KDM4EMAPT | |
| SCHEMBL4944223 | 0.85 | ALDH1A1 (0.45) | OXTRAVPR1AALDH1A1KDM4EMAPT | |
| SCHEMBL6109720 | 0.84 | OXTR (0.64) | OXTRAVPR1AALDH1A1MAPTSMN1; SMN2 | |
| SCHEMBL4949419 | 0.82 | HPGD (0.43) | OXTRALDH1A1KDM4EMAPTHSD17B10 | |
| SCHEMBL4949424 | 0.82 | HPGD (0.43) | OXTRALDH1A1KDM4EMAPTHSD17B10 | |
| SCHEMBL4943178 | 0.80 | ALDH1A1 (0.41) | OXTRAVPR1AALDH1A1KDM4EMAPT | |
| SCHEMBL4943171 | 0.80 | ALDH1A1 (0.41) | OXTRAVPR1AALDH1A1KDM4EMAPT | |
| SCHEMBL5482133 | 0.78 | OXTR (0.68) | OXTRAVPR1AMEN1KMT2AHPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1268418-A1 | PHARMACEUTICALLY ACTIVE PYRROLIDINE DERIVATIVES AS BAX INHIBITORS | Applied Research Systems ARS Holding N.V. (AN) | 2003-01-02 | — | — | EP | claimed |
| WO-2001074769-A1 | PHARMACEUTICALLY ACTIVE PYRROLIDINE DERIVATIVES AS BAX INHIBITORS | APPLIED RESEARCH SYSTEMS ARS HOLDING N.V. (AN) | 2001-10-11 | — | — | WO | claimed |
| EP-1268419-A1 | PYRROLIDINE DERIVATIVES USEFUL AS BAX INHIBITORS | Applied Research Systems ARS Holding N.V. (AN) | 2003-01-02 | — | — | EP | disclosed |
| WO-2001072705-A1 | PHARMACEUTICALLY ACTIVE PYRROLIDINE DERIVATIVES AS BAX INHIBITORS | APPLIED RESEARCH SYSTEMS ARS HOLDING N.V. (AN) | 2001-10-04 | — | — | WO | disclosed |