SCHEMBL7089541

SCHEMBL7089541

COc1ccc(SC)cc1C=O

nearest known ligand 0.52

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 5/20 0.52
TSHR P16473 2/20 0.52
KDM4E B2RXH2 1/20 0.52
TDP1 Q9NUW8 1/20 0.52
CYP1A1 P04798 7/20 0.50
CYP1B1 Q16678 7/20 0.50
CYP1A2 P05177 6/20 0.50
PRKDC P78527 1/20 0.47
TUBB1 Q9H4B7 2/20 0.44
GAA P10253 1/20 0.43
LMNA P02545 1/20 0.42
HPGD P15428 1/20 0.42
ERN1 O75460 2/20 0.41
TLR2 O60603 1/20 0.41
TLR1 Q15399 1/20 0.41
TLR6 Q9Y2C9 1/20 0.41
AOX1 Q06278 1/20 0.41
TUBB4A P04350 1/20 0.41
TUBB P07437 1/20 0.41
TUBA3C P0DPH7 1/20 0.41

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL5103444 0.87 ALDH1A1 (0.53) ALDH1A1TSHRKDM4ETDP1CYP1A1
SCHEMBL5107347 0.85 ALDH1A1 (0.59) ALDH1A1TSHRKDM4ETDP1CYP1A1
SCHEMBL7818843 0.82 ALDH1A1 (0.48) ALDH1A1TSHRKDM4ETDP1CYP1A1
SCHEMBL7819802 0.80 ALDH1A1 (0.46) ALDH1A1TSHRKDM4ETDP1CYP1A1
SCHEMBL9825309 0.79 GCK (0.39) ALDH1A1KDM4ETDP1CYP1A1CYP1B1
SCHEMBL3511079 0.76 CYP1A1 (0.50) ALDH1A1TSHRTDP1CYP1A1CYP1B1
SCHEMBL5723652 0.75 CYP1A1 (0.51) ALDH1A1TSHRKDM4ETDP1CYP1A1
SCHEMBL7810762 0.75 MAOA (0.46) ALDH1A1TSHRKDM4ETDP1PRKDC
SCHEMBL7669934 0.75 PDE4B (0.37) ALDH1A1HPGD
SCHEMBL8154576 0.75 GCK (0.60) ALDH1A1KDM4ETDP1LMNAHPGD

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0665843-B1 SUBSTITUTED QUINUCLIDINES AS SUBSTANCE P ANTAGONISTS PFIZER (US) 2003-08-13 EP disclosed
EP-0655996-B1 SUBSTITUTED BENZYLAMINO NITROGEN CONTAINING NON-AROMATIC HETEROCYCLES PFIZER (US) 2001-11-07 EP disclosed
EP-1114823-A2 Substituted benzylamino nitrogen containing non-aromatic heterocycles PFIZER INC. (US) 2001-07-11 EP disclosed
US-5837711-A Substituted quinuclidines as substance P antagonists PFIZER INC. (US) 1998-11-17 US disclosed
US-5721255-A Substituted benzylamino nitrogen containing non-aromatic heterocycles PFIZER INC. (US) 1998-02-24 US disclosed
EP-0665843-A1 SUBSTITUTED QUINUCLIDINES AS SUBSTANCE P ANTAGONISTS PFIZER INC. (US) 1995-08-09 EP disclosed
EP-0655996-A1 SUBSTITUTED BENZYLAMINO NITROGEN CONTAINING NON-AROMATIC HETEROCYCLES PFIZER INC. (US) 1995-06-07 EP disclosed
WO-1994004496-A9 SUBSTITUTED BENZYLAMINO NITROGEN CONTAINING NON-AROMATIC HETEROCYCLES 1995-01-26 WO disclosed
WO-1994010170-A1 SUBSTITUTED QUINUCLIDINES AS SUBSTANCE P ANTAGONISTS PFIZER INC. (US) 1994-05-11 WO disclosed
WO-1994004496-A1 SUBSTITUTED BENZYLAMINO NITROGEN CONTAINING NON-AROMATIC HETEROCYCLES PFIZER INC. (US) 1994-03-03 WO disclosed