SCHEMBL7819802

SCHEMBL7819802

COc1ccc(SC(F)(F)F)cc1C=O

nearest known ligand 0.46

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 6/20 0.46
TSHR P16473 2/20 0.46
KDM4E B2RXH2 1/20 0.46
TDP1 Q9NUW8 1/20 0.46
PRKDC P78527 1/20 0.42
TUBB1 Q9H4B7 1/20 0.40
L3MBTL1 Q9Y468 1/20 0.39
LMNA P02545 3/20 0.38
HPGD P15428 1/20 0.38
ERN1 O75460 5/20 0.38
SMN1; SMN2 Q16637 1/20 0.38
RXFP1 Q9HBX9 1/20 0.38
TLR2 O60603 1/20 0.37
TLR1 Q15399 1/20 0.37
TLR6 Q9Y2C9 1/20 0.37
AOX1 Q06278 1/20 0.37
CYP1A1 P04798 1/20 0.36
CYP1A2 P05177 1/20 0.36
CYP1B1 Q16678 1/20 0.36
MAPT P10636 1/20 0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL5103444 0.81 ALDH1A1 (0.53) ALDH1A1TSHRKDM4ETDP1PRKDC
SCHEMBL7089541 0.80 ALDH1A1 (0.52) ALDH1A1TSHRKDM4ETDP1PRKDC
SCHEMBL7818843 0.77 ALDH1A1 (0.48) ALDH1A1TSHRKDM4ETDP1PRKDC
SCHEMBL15697534 0.76 ALDH1A1 (0.39) ALDH1A1TSHRKDM4ETDP1LMNA
SCHEMBL15191821 0.75 ENPP2 (0.43) ALDH1A1KDM4ETDP1TUBB1LMNA
SCHEMBL1186123 0.75 ALDH1A1 (0.50) ALDH1A1TSHRKDM4ETDP1PRKDC
SCHEMBL20745926 0.75 ALDH1A1 (0.43) ALDH1A1KDM4ETDP1TUBB1L3MBTL1
SCHEMBL22620380 0.75 ALDH1A1 (0.48) ALDH1A1TSHRKDM4ETDP1TUBB1
SCHEMBL11065353 0.75 ALDH1A1 (0.38) ALDH1A1TSHRKDM4ETDP1LMNA
SCHEMBL10916030 0.75 ERN1 (0.47) ALDH1A1TSHRKDM4ETDP1LMNA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0655996-B1 SUBSTITUTED BENZYLAMINO NITROGEN CONTAINING NON-AROMATIC HETEROCYCLES PFIZER (US) 2001-11-07 EP disclosed
EP-1114823-A2 Substituted benzylamino nitrogen containing non-aromatic heterocycles PFIZER INC. (US) 2001-07-11 EP disclosed
US-5721255-A Substituted benzylamino nitrogen containing non-aromatic heterocycles PFIZER INC. (US) 1998-02-24 US disclosed
EP-0655996-A1 SUBSTITUTED BENZYLAMINO NITROGEN CONTAINING NON-AROMATIC HETEROCYCLES PFIZER INC. (US) 1995-06-07 EP disclosed
WO-1994004496-A9 SUBSTITUTED BENZYLAMINO NITROGEN CONTAINING NON-AROMATIC HETEROCYCLES 1995-01-26 WO disclosed
WO-1994004496-A1 SUBSTITUTED BENZYLAMINO NITROGEN CONTAINING NON-AROMATIC HETEROCYCLES PFIZER INC. (US) 1994-03-03 WO disclosed