SCHEMBL7089550

SCHEMBL7089550

CCC(=O)Nc1cc(C)c(Oc2ccc3[nH]cc(C(C)C)c3c2)c(C)c1

nearest known ligand 0.77

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
THRA P10827 16/20 0.77
THRB P10828 16/20 0.77

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6511153 0.91 THRA (0.72) THRATHRB
SCHEMBL6513266 0.90 THRA (0.75) THRATHRB
SCHEMBL7085384 0.87 THRA (1.00) THRATHRB
SCHEMBL7088287 0.86 THRA (0.78) THRATHRB
SCHEMBL7089419 0.85 THRA (0.77) THRATHRB
SCHEMBL6512955 0.84 THRB (0.82) THRATHRB
SCHEMBL6512201 0.84 THRA (0.67) THRATHRB
SCHEMBL6512163 0.84 THRB (1.00) THRATHRB
SCHEMBL6512881 0.84 THRB (0.81) THRATHRB
SCHEMBL6519364 0.84 THRB (0.81) THRATHRB

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1347959-A1 INDOLE DERIVATIVES AS LIGANDS OF THYROID RECEPTORS Bayer Aktiengesellschaft (DE) 2003-10-01 EP disclosed
WO-2002051805-A1 INDOLE DERIVATIVES AS LIGANDS OF THYROID RECEPTORS BAYER AKTIENGESELLSCHAFT (DE) 2002-07-04 WO disclosed