SCHEMBL7089752

SCHEMBL7089752

COCCc1nc2c(N)nc3ccccc3c2n1CCOCCNC(=O)N(C)c1ccccc1

nearest known ligand 0.55

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
TLR7 Q9NYK1 19/20 0.55
TLR8 Q9NR97 1/20 0.50

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL14592836 0.92 TLR7 (0.61) TLR7
SCHEMBL6813136 0.88 TLR7 (0.56) TLR7TLR8
SCHEMBL6098376 0.87 TLR7 (0.62) TLR7TLR8
SCHEMBL6031989 0.87 TLR7 (0.60) TLR7TLR8
SCHEMBL6098681 0.86 TLR7 (0.56) TLR7TLR8
SCHEMBL7102928 0.85 TLR7 (0.43) TLR7
SCHEMBL29714531 0.85 TLR7 (0.55) TLR7TLR8
SCHEMBL4338064 0.85 TLR7 (0.55) TLR7TLR8
SCHEMBL18587605 0.85 TLR8 (0.55) TLR7TLR8
SCHEMBL1044159 0.84 TLR7 (0.57) TLR7TLR8

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-6656938-B2 Inducing cytokine biosynthesis in animals, for the treatment of diseases, including viral and neoplastic diseases 3M INNOVATIVE PROPERTIES COMPANY 2003-12-02 US disclosed
EP-1343784-A2 UREA SUBSTITUTED IMIDAZOQUINOLINE ETHERS 3M Innovative Properties Company (US) 2003-09-17 EP disclosed
US-20030158192-A1 Urea substituted imidazoquinoline ethers 3M INNOVATIVE PROPERTIES COMPANY 2003-08-21 US disclosed
WO-2002046191-A2 UREA SUBSTITUTED IMIDAZOQUINOLINE ETHERS 3M INNOVATIVE PROPERTIES COMPANY (US) 2002-06-13 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20030158192-A1 Urea substituted imidazoquinoline ethers IRF3, EIF2AK2, IFNG TLR7 84/4885TLR8 273/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.