Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.56 |
| ▸ | MEN1 | O00255 | 4/20 | 0.54 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.54 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.54 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.54 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.54 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.54 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.54 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.54 |
| ▸ | HTT | P42858 | 3/20 | 0.54 |
| ▸ | LMNA | P02545 | 4/20 | 0.53 |
| ▸ | SMN1; SMN2 | Q16637 | 6/20 | 0.52 |
| ▸ | TSHR | P16473 | 4/20 | 0.52 |
| ▸ | NPC1 | O15118 | 2/20 | 0.52 |
| ▸ | RAB9A | P51151 | 1/20 | 0.52 |
| ▸ | GAA | P10253 | 2/20 | 0.51 |
| ▸ | OPRK1 | P41145 | 2/20 | 0.51 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.51 |
| ▸ | MAPT | P10636 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3915525 | 0.86 | ALDH1A1 (0.67) | KDM4EMEN1KMT2ACYP3A4CYP2C19 | |
| SCHEMBL3910599 | 0.83 | ALDH1A1 (0.60) | KDM4EMEN1KMT2ACYP3A4CYP2C19 | |
| SCHEMBL4211347 | 0.78 | TSHR (0.56) | MEN1KMT2ACYP3A4CYP2C19CYP1A2 | |
| SCHEMBL6402415 | 0.77 | ALDH1A1 (0.74) | KDM4EALDH1A1LMNASMN1; SMN2TSHR | |
| SCHEMBL6410240 | 0.77 | MEN1 (0.70) | KDM4EMEN1KMT2ACYP3A4CYP2C19 | |
| SCHEMBL3904873 | 0.76 | TSHR (0.67) | KDM4EMEN1KMT2ACYP3A4ALDH1A1 | |
| SCHEMBL4218132 | 0.76 | ALDH1A1 (0.63) | KDM4EMEN1KMT2AALDH1A1HTT | |
| SCHEMBL15983422 | 0.75 | ALDH1A1 (0.80) | KDM4EMEN1KMT2AALDH1A1LMNA | |
| SCHEMBL4204703 | 0.74 | SMN1; SMN2 (0.61) | CYP3A4CYP2C19CYP1A2CYP2C9ALDH1A1 | |
| SCHEMBL4215484 | 0.74 | ALDH1A1 (0.69) | KDM4EMEN1KMT2ACYP3A4CYP2C19 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1357913-A1 | HETEROCYCLIC INHIBITORS OF GLYCINE TRANSPORTER 2 | TELIK, INC. (US) | 2003-11-05 | — | — | EP | claimed |
| WO-2002064135-A1 | HETEROCYCLIC INHIBITORS OF GLYCINE TRANSPORTER 2 | TELIK, INC. (US) | 2002-08-22 | — | — | WO | claimed |
| EP-1357913-A1 | HETEROCYCLIC INHIBITORS OF GLYCINE TRANSPORTER 2 | TELIK, INC. (US) | 2003-11-05 | — | — | EP | disclosed |
| WO-2002064135-A1 | HETEROCYCLIC INHIBITORS OF GLYCINE TRANSPORTER 2 | TELIK, INC. (US) | 2002-08-22 | — | — | WO | disclosed |