Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.67 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.67 |
| ▸ | NPC1 | O15118 | 4/20 | 0.67 |
| ▸ | TSHR | P16473 | 3/20 | 0.67 |
| ▸ | RAB9A | P51151 | 2/20 | 0.67 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.64 |
| ▸ | MEN1 | O00255 | 3/20 | 0.63 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.63 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.61 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.61 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.61 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.61 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.61 |
| ▸ | LMNA | P02545 | 3/20 | 0.60 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.60 |
| ▸ | HTT | P42858 | 2/20 | 0.57 |
| ▸ | GAA | P10253 | 1/20 | 0.57 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.57 |
| ▸ | SSTR4 | P31391 | 1/20 | 0.56 |
| ▸ | SSTR3 | P32745 | 1/20 | 0.56 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3910599 | 0.93 | ALDH1A1 (0.60) | ALDH1A1SMN1; SMN2NPC1TSHRRAB9A | |
| SCHEMBL6410240 | 0.90 | MEN1 (0.70) | ALDH1A1SMN1; SMN2NPC1TSHRRAB9A | |
| SCHEMBL3904873 | 0.88 | TSHR (0.67) | ALDH1A1SMN1; SMN2NPC1TSHRRAB9A | |
| SCHEMBL15983422 | 0.88 | ALDH1A1 (0.80) | ALDH1A1SMN1; SMN2NPC1TSHRRAB9A | |
| SCHEMBL7090430 | 0.86 | KDM4E (0.56) | ALDH1A1SMN1; SMN2NPC1TSHRRAB9A | |
| SCHEMBL6403164 | 0.83 | LMNA (0.65) | ALDH1A1SMN1; SMN2NPC1TSHRRAB9A | |
| SCHEMBL3902836 | 0.81 | TSHR (0.79) | ALDH1A1SMN1; SMN2NPC1TSHRRAB9A | |
| SCHEMBL3910198 | 0.81 | OPRK1 (0.86) | NPC1TSHRRAB9ALMNAOPRK1 | |
| SCHEMBL4205191 | 0.81 | KDM4E (0.51) | ALDH1A1SMN1; SMN2NPC1TSHRRAB9A | |
| SCHEMBL28483626 | 0.81 | TSHR (0.64) | ALDH1A1NPC1TSHRRAB9AKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2005090320-A2 | TRIAZOLE DERIVATIVES AND METHOD OF USING THE SAME TO TREAT HIV INFECTIONS | WYETH (US) | 2005-09-29 | — | — | WO | claimed |
| US-20050209287-A1 | Triazole derivatives and method of using the same to treat HIV infections | WYETH | 2005-09-22 | — | — | US | claimed |
| US-7563905-B2 | Triazole derivatives and method of using the same to treat HIV infections | WYETH (US) | 2009-07-21 | — | — | US | disclosed |
| WO-2005090320-A2 | TRIAZOLE DERIVATIVES AND METHOD OF USING THE SAME TO TREAT HIV INFECTIONS | WYETH (US) | 2005-09-29 | — | — | WO | disclosed |
| US-20050209287-A1 | Triazole derivatives and method of using the same to treat HIV infections | WYETH | 2005-09-22 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050209287-A1 | Triazole derivatives and method of using the same to treat HIV infections | CYP3A43, XDH, AKR1C3 | ALDH1A1 430/4885SMN1; SMN2 3822/4885NPC1 509/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.