Known targets — ChEMBL curated mechanism
ADRA2AADRA2BADRA2CADRB2AGTR1AVPR1AAVPR1BAVPR2BDKRB2CALCRCHRNA3CHRNB4ESR1ESR2GHSRGNRHRGSC1HSPA8MALT1MC1RMC4RNOS1NOS2NOS3OPRK1OXTRRAMP1RAMP2RAMP3SCN5ASSTR1SSTR2SSTR3SSTR4SSTR5dacAdacBdacCfolPftsImrcAmrcBmrdArplArplBrplCrplDrplErplFrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmFrpmGrpmHrpmIrpmJrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUykgMykgO
The experimentally established mechanism targets of Acetic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 2/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.32 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.32 |
| ▸ | TSHR | P16473 | 1/20 | 0.31 |
| ▸ | THRB | P10828 | 1/20 | 0.31 |
| ▸ | CDK1 | P06493 | 1/20 | 0.31 |
| ▸ | CCNB1 | P14635 | 1/20 | 0.31 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.31 |
| ▸ | CDK2 | P24941 | 1/20 | 0.31 |
| ▸ | CCNA1 | P78396 | 1/20 | 0.31 |
| ▸ | FFAR3 | O14843 | 1/20 | 0.30 |
| ▸ | LCK | P06239 | 1/20 | 0.30 |
| ▸ | FYN | P06241 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1397073 | 0.86 | — | — | |
| SCHEMBL12842503 | 0.86 | — | — | |
| Acetic Acid SCHEMBL28064673 | 0.82 | ALDH1A1 (0.42) | TDP1ALDH1A1TSHR | |
| SCHEMBL27646263 | 0.81 | LMNA (0.41) | TDP1LMNATHRBCDK1CCNB1 | |
| SCHEMBL22499768 | 0.81 | LMNA (0.41) | TDP1LMNATHRBCDK1CCNB1 | |
| Acetic Acid SCHEMBL8377984 | 0.81 | TDP1 (0.52) | TDP1LMNAHSD17B10TSHR | |
| Acetic Acid SCHEMBL1880325 | 0.79 | FFAR3 (0.35) | TDP1ALDH1A1HSD17B10TSHRFFAR3 | |
| Acetic Acid SCHEMBL7262426 | 0.79 | FFAR3 (0.35) | TDP1ALDH1A1HSD17B10TSHRFFAR3 | |
| Acetic Acid SCHEMBL5485514 | 0.79 | FFAR3 (0.35) | TDP1ALDH1A1TSHRFFAR3LCK | |
| Acetic Acid SCHEMBL13719102 | 0.79 | FFAR3 (0.35) | TDP1ALDH1A1HSD17B10TSHRFFAR3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6576397-B2 | Digital infrared laser scanning; computer-to-plate; handling in a bright room; alkali soluble polymer having addition polymerizable unsaturated bonds; initiator; water soluble polyvinyl alcohol overcoat | FUJI PHOTO FILM CO., LTD. (JP) | 2003-06-10 | — | — | US | disclosed |
| US-20010003643-A1 | Precursor, comprising a support having a hydrophilic surface on which a thermal polymerization layer comprising a polymer having addition polymerizable unsaturated bond and a initiator; a water soluble overcoat of polyvinyl alcohol | FUJIFILM CORPORATION (JP) | 2001-06-14 | — | — | US | disclosed |