Known targets — ChEMBL curated mechanism
ACHECHRM1CHRM3CHRNA1CHRNB1CHRNDCHRNECHRNG
The experimentally established mechanism targets of Iodide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACHE known ✓ | P22303 | 3/20 | 0.50 |
| ▸ | LMNA | P02545 | 2/20 | 0.50 |
| ▸ | TSHR | P16473 | 1/20 | 0.50 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.50 |
| ▸ | HPGD | P15428 | 3/20 | 0.42 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.42 |
| ▸ | CES2 | O00748 | 1/20 | 0.39 |
| ▸ | CES1 | P23141 | 1/20 | 0.39 |
| ▸ | NPC1 | O15118 | 4/20 | 0.35 |
| ▸ | RAB9A | P51151 | 4/20 | 0.35 |
| ▸ | POLB | P06746 | 2/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.35 |
| ▸ | HTT | P42858 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.35 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.35 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.35 |
| ▸ | RELA | Q04206 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Iodide SCHEMBL2955653 | 1.00 | ACHE (0.50) | ACHELMNATSHRALOX12HPGD | |
| SCHEMBL425893 | 0.97 | ACHE (0.53) | ACHELMNATSHRALOX12HPGD | |
| SCHEMBL47574 | 0.97 | ACHE (0.53) | ACHELMNATSHRALOX12HPGD | |
| Bromide SCHEMBL3139967 | 0.95 | ACHE (0.50) | ACHELMNATSHRALOX12HPGD | |
| Hydrochloric Acid SCHEMBL5709632 | 0.95 | ACHE (0.50) | ACHELMNATSHRALOX12HPGD | |
| Bromide SCHEMBL136724 | 0.95 | ACHE (0.50) | ACHELMNATSHRALOX12HPGD | |
| P-Xylene SCHEMBL4152294 | 0.95 | ACHE (0.56) | ACHELMNATSHRALOX12HPGD | |
| SCHEMBL29968520 | 0.90 | ACHE (0.46) | ACHELMNATSHRALOX12HPGD | |
| Iodide SCHEMBL8433250 | 0.89 | ACHE (0.53) | ACHELMNATSHRALOX12TDP1 | |
| SCHEMBL3144680 | 0.88 | ACHE (0.43) | ACHELMNATSHRALOX12HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1160095-B1 | Heat-sensitive composition and planographic printing plate precursor | FUJIFILM CORP (JP) | 2013-12-25 | — | — | EP | disclosed |
| US-6660446-B2 | Generating acid upon heating | FUJI PHOTO FILM CO., LTD. (JP) | 2003-12-09 | — | — | US | disclosed |
| US-20020025489-A1 | Generating acid upon heating | FUJIFILM CORPORATION (JP) | 2002-02-28 | — | — | US | disclosed |
| EP-1160095-A2 | Heat-sensitive composition and planographic printing plate precursor | FUJI PHOTO FILM CO., LTD. (JP) | 2001-12-05 | — | — | EP | disclosed |