Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DDX3X | O00571 | 2/20 | 0.79 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.64 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.64 |
| ▸ | PKM | P14618 | 1/20 | 0.64 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.64 |
| ▸ | SAE1 | Q9UBE0 | 1/20 | 0.62 |
| ▸ | UBA2 | Q9UBT2 | 1/20 | 0.62 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.61 |
| ▸ | NPC1 | O15118 | 5/20 | 0.59 |
| ▸ | RAB9A | P51151 | 5/20 | 0.59 |
| ▸ | POLB | P06746 | 1/20 | 0.57 |
| ▸ | GBA1 | P04062 | 1/20 | 0.57 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.57 |
| ▸ | MEN1 | O00255 | 2/20 | 0.56 |
| ▸ | MAPT | P10636 | 1/20 | 0.56 |
| ▸ | CASP3 | P42574 | 1/20 | 0.56 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.56 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.56 |
| ▸ | CSF1R | P07333 | 1/20 | 0.56 |
| ▸ | FLT1 | P17948 | 1/20 | 0.56 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1657499 | 0.89 | DDX3X (1.00) | DDX3XSMN1; SMN2KMT2AALDH1A1NPC1 | |
| SCHEMBL30314470 | 0.89 | DDX3X (1.00) | DDX3XSMN1; SMN2KMT2AALDH1A1NPC1 | |
| SCHEMBL4416620 | 0.89 | SMN1; SMN2 (0.77) | SMN1; SMN2KMT2APKMALDH1A1SAE1 | |
| SCHEMBL29703055 | 0.89 | SMN1; SMN2 (0.77) | SMN1; SMN2KMT2APKMALDH1A1SAE1 | |
| SCHEMBL13724310 | 0.88 | SAE1 (0.69) | DDX3XSMN1; SMN2KMT2APKMALDH1A1 | |
| SCHEMBL14350754 | 0.88 | DDX3X (0.77) | DDX3XSMN1; SMN2KMT2APKMALDH1A1 | |
| SCHEMBL31054278 | 0.84 | SMN1; SMN2 (0.75) | SMN1; SMN2KMT2APKMALDH1A1SAE1 | |
| SCHEMBL259602 | 0.84 | SMN1; SMN2 (0.75) | SMN1; SMN2KMT2APKMALDH1A1SAE1 | |
| SCHEMBL711068 | 0.84 | DDX3X (0.89) | DDX3XSMN1; SMN2KMT2AALDH1A1HSD17B10 | |
| SCHEMBL5852140 | 0.82 | SAE1 (0.76) | SMN1; SMN2KMT2APKMALDH1A1SAE1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-108794408-B | Pyrimidine phenylurea anti-tumor compound and preparation method and application thereof | 中国医科大学 | 2020-04-21 | — | — | CN | disclosed |
| CN-108794408-A | Pyrimidine phenylurea anti-tumor compounds and its preparation method and application | 中国医科大学 | 2018-11-13 | — | — | CN | disclosed |
| US-8124759-B2 | Inhibitors of protein kinases | ABBOTT LABORATORIES (US) | 2012-02-28 | — | — | US | disclosed |
| EP-2150553-B1 | CONDENSED HETEROCYCLIC COMPOUNDS AS INHIBITORS OF PROTEIN KINASES | ABBOTT LAB (US) | 2011-10-05 | — | — | EP | disclosed |
| EP-2297151-A1 | INHIBITORS OF PROTEIN KINASES | Abbott Laboratories (US) | 2011-03-23 | — | — | EP | disclosed |
| EP-2150553-A1 | CONDENSED HETEROCYCLIC COMPOUNDS AS INHIBITORS OF PROTEIN KINASES | Abbott Laboratories (US) | 2010-02-10 | — | — | EP | disclosed |
| WO-2009136966-A1 | INHIBITORS OF PROTEIN KINASES | ABBOTT LABORATORIES (US) | 2009-11-12 | — | — | WO | disclosed |
| US-20090131425-A1 | INHIBITORS OF PROTEIN KINASES | ABBOTT LABORATORIES (US) | 2009-05-21 | — | — | US | disclosed |
| US-20090023743-A1 | INHIBITORS OF PROTEIN KINASES | ABBOTT LABORATORIES (IL) | 2009-01-22 | — | — | US | disclosed |
| WO-2008141145-A1 | CONDENSED HETEROCYCLIC COMPOUNDS AS INHIBITORS OF PROTEIN KINASES | ABBOTT LABORATORIES (US) | 2008-11-20 | — | — | WO | disclosed |
| WO-2008141140-A1 | CONDENSED HETEROCYCLIC COMPOUNDS AS INHIBITORS OF PROTEIN KINASES | ABBOTT LABORATORIES (US) | 2008-11-20 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090131425-A1 | INHIBITORS OF PROTEIN KINASES | AURKC, AURKB, PLK1 | DDX3X 1508/4885SMN1; SMN2 2414/4885KMT2A 1632/4885 |
| US-20090023743-A1 | INHIBITORS OF PROTEIN KINASES | AURKC, AURKB, PLK1 | DDX3X 1508/4885SMN1; SMN2 2414/4885KMT2A 1632/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.