Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 2/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.49 |
| ▸ | HDAC1 | Q13547 | 3/20 | 0.49 |
| ▸ | TUBB4A | P04350 | 4/20 | 0.48 |
| ▸ | TUBB | P07437 | 4/20 | 0.48 |
| ▸ | TUBA3C | P0DPH7 | 4/20 | 0.48 |
| ▸ | TUBA1B | P68363 | 4/20 | 0.48 |
| ▸ | TUBA4A | P68366 | 4/20 | 0.48 |
| ▸ | TUBB4B | P68371 | 4/20 | 0.48 |
| ▸ | TUBB3 | Q13509 | 4/20 | 0.48 |
| ▸ | TUBB2A | Q13885 | 4/20 | 0.48 |
| ▸ | TUBB8 | Q3ZCM7 | 4/20 | 0.48 |
| ▸ | TUBA3E | Q6PEY2 | 4/20 | 0.48 |
| ▸ | TUBA1A | Q71U36 | 4/20 | 0.48 |
| ▸ | TUBA1C | Q9BQE3 | 4/20 | 0.48 |
| ▸ | TUBB6 | Q9BUF5 | 4/20 | 0.48 |
| ▸ | TUBB2B | Q9BVA1 | 4/20 | 0.48 |
| ▸ | TUBB1 | Q9H4B7 | 4/20 | 0.48 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.47 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL708380 | 0.83 | LPAR1 (0.51) | POLBKDM4EHDAC1NPSR1ALDH1A1 | |
| SCHEMBL708371 | 0.77 | POLB (0.54) | POLBKDM4ELMNAALDH1A1RECQL | |
| SCHEMBL707552 | 0.69 | POLB (0.50) | POLBKDM4EHDAC1HDAC8NPSR1 | |
| SCHEMBL706891 | 0.69 | KMT2A (0.42) | POLBKDM4EHDAC1HDAC8NPSR1 | |
| SCHEMBL427783 | 0.68 | TUBB4A (0.55) | KDM4EHDAC1TUBB4ATUBBTUBA3C | |
| SCHEMBL708379 | 0.68 | POLB (0.51) | POLBKDM4ELMNAALDH1A1RECQL | |
| SCHEMBL707714 | 0.67 | LPAR1 (0.51) | POLBKDM4ENPSR1LMNAALDH1A1 | |
| SCHEMBL704971 | 0.67 | PPARG (0.48) | POLBKDM4ELMNAALDH1A1RECQL | |
| SCHEMBL707130 | 0.66 | PPARG (0.54) | POLBKDM4ELMNA | |
| SCHEMBL15135930 | 0.66 | TUBB4A (0.48) | HDAC1TUBB4ATUBBTUBA3CTUBA1B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1553075-B1 | LPA RECEPTOR ANTAGONISTS | ONO PHARMACEUTICAL CO (JP) | 2013-08-14 | — | — | EP | disclosed |
| EP-2565178-A1 | LPA Receptor Antagonists | ONO PHARMACEUTICAL CO., LTD. (JP) | 2013-03-06 | — | — | EP | disclosed |
| US-20120088782-A1 | LPA RECEPTOR ANTAGONIST | ONO PHARMACEUTICAL CO., LTD. (JP) | 2012-04-12 | — | — | US | disclosed |
| US-8124645-B2 | LPA receptor antagonist | ONO PHARMACEUTICAL CO., LTD. (JP) | 2012-02-28 | — | — | US | disclosed |
| US-7820682-B2 | LPA receptor antagonist | ONO PHARMACEUTICAL CO., LTD. (JP) | 2010-10-26 | — | — | US | disclosed |
| US-20100249157-A2 | LPA RECEPTOR ANTAGONIST | ONO PHARMACEUTICAL CO., LTD. (JP) | 2010-09-30 | — | — | US | disclosed |
| US-20080293764-A1 | LPA RECEPTOR ANTAGONIST | ONO PHARMACEUTICAL CO., LTD. | 2008-11-27 | — | — | US | disclosed |
| US-20060148830-A1 | Lpa receptor antagonist | ONO PHARMACEUTICAL CO., LTD. | 2006-07-06 | — | — | US | disclosed |
| EP-1553075-A1 | LPA RECEPTOR ANTAGONISTS | ONO PHARMACEUTICAL CO., LTD. (JP) | 2005-07-13 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080293764-A1 | LPA RECEPTOR ANTAGONIST | LPAR1, LPAR2, LPAR4 | POLB 1235/4885KDM4E 4132/4885HDAC1 983/4885 |
| US-20100249157-A2 | LPA RECEPTOR ANTAGONIST | LPAR1, LPAR2, LPAR4 | POLB 1235/4885KDM4E 4132/4885HDAC1 983/4885 |
| US-20120088782-A1 | LPA RECEPTOR ANTAGONIST | LPAR1, LPAR2, LPAR4 | POLB 1235/4885KDM4E 4132/4885HDAC1 983/4885 |
| US-20060148830-A1 | Lpa receptor antagonist | LPAR1, LPAR2, LPAR4 | POLB 1235/4885KDM4E 4132/4885HDAC1 983/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.