SCHEMBL7091482

SCHEMBL7091482

CN(CC(=O)Nc1ccccc1N)C(=O)OC(C)(C)C

nearest known ligand 0.48

Predicted protein targets (top 18)

geneUniProtsupporting neighboursconfidence
HDAC3 O15379 14/20 0.48
HDAC1 Q13547 13/20 0.48
HDAC2 Q92769 9/20 0.48
HDAC10 Q969S8 7/20 0.48
HDAC6 Q9UBN7 6/20 0.48
NCOR2 Q9Y618 5/20 0.48
HDAC4 P56524 5/20 0.48
HDAC7 Q8WUI4 5/20 0.48
HDAC11 Q96DB2 5/20 0.48
HDAC8 Q9BY41 5/20 0.48
HDAC9 Q9UKV0 5/20 0.48
HDAC5 Q9UQL6 5/20 0.48
CA1 P00915 1/20 0.46
CA2 P00918 1/20 0.46
TDP1 Q9NUW8 1/20 0.43
AAK1 Q2M2I8 1/20 0.41
SMN1; SMN2 Q16637 1/20 0.41
ALDH1A1 P00352 1/20 0.40

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL937773 0.81 KMT2A (0.45) SMN1; SMN2ALDH1A1
SCHEMBL19675815 0.81 PRSS1 (0.43) HDAC1SMN1; SMN2ALDH1A1
SCHEMBL15766953 0.80 LMNA (0.59) SMN1; SMN2ALDH1A1
SCHEMBL19057816 0.79 METAP2 (0.44) HDAC3HDAC1HDAC2HDAC10HDAC6
SCHEMBL19675697 0.77 ALDH1A1 (0.48) HDAC3HDAC1HDAC2HDAC10HDAC6
Anthranilamide SCHEMBL18824334 0.77 NPC1 (0.41) HDAC3HDAC1HDAC2HDAC10HDAC6
SCHEMBL15584453 0.75 AAK1 (0.53) HDAC3HDAC1HDAC2HDAC10HDAC6
SCHEMBL29353000 0.75 HDAC1 (0.52) HDAC3HDAC1HDAC2HDAC10HDAC6
SCHEMBL211033 0.75 HDAC1 (0.52) HDAC3HDAC1HDAC2HDAC10HDAC6
SCHEMBL5493765 0.75 CA1 (0.33) CA1CA2TDP1AAK1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0910563-B1 INTEGRIN RECEPTOR ANTAGONISTS SMITHKLINE BEECHAM CORP (US) 2003-05-02 EP disclosed
EP-0767792-A4 VITRONECTIN RECEPTOR ANTAGONISTS SMITHKLINE BEECHAM CORP (US) 2002-11-20 EP disclosed
US-6008213-A A INHIBITOR OF VITRONECTIN RECEPTOR AND FIBRINOGEN RECEPTOR; USEFUL FOR INHIBITING PLATELET AGGREGATION AND OSTEOPOROSIS SMITHKLINE BEECHAM CORPORATION (US) 1999-12-28 US disclosed
US-5977101-A Benzimidazoles/Imidazoles Linked to a Fibrinogen Receptor Antagonist Template Having Vitronectin Receptor Antagonist Activity SMITHKLINE BEECHAM CORPORATION (US) 1999-11-02 US disclosed
EP-0910563-A4 1999-04-28 EP disclosed
EP-0910563-A1 INTEGRIN RECEPTOR ANTAGONISTS SMITHKLINE BEECHAM CORPORATION (US) 1999-04-28 EP disclosed
EP-0767792-A1 VITRONECTIN RECEPTOR ANTAGONISTS SMITHKLINE BEECHAM CORPORATION (US) 1997-04-16 EP disclosed
WO-1997001540-A1 INTEGRIN RECEPTOR ANTAGONISTS SMITHKLINE BEECHAM CORPORATION (US) 1997-01-16 WO disclosed
WO-1996000730-A1 VITRONECTIN RECEPTOR ANTAGONISTS SMITHKLINE BEECHAM CORPORATION (US) 1996-01-11 WO disclosed