Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA2 | P00918 | 1/20 | 0.42 |
| ▸ | CA9 | Q16790 | 1/20 | 0.42 |
| ▸ | HSD11B1 | P28845 | 3/20 | 0.41 |
| ▸ | CAPN1 | P07384 | 2/20 | 0.40 |
| ▸ | MAPT | P10636 | 4/20 | 0.38 |
| ▸ | POLB | P06746 | 2/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.38 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.38 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.38 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | RECQL | P46063 | 1/20 | 0.38 |
| ▸ | TP53 | P04637 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11701961 | 0.85 | CA2 (0.41) | CA2CA9HSD11B1CAPN1MAPT | |
| SCHEMBL6800970 | 0.83 | HSD11B1 (0.40) | CA2CA9HSD11B1CAPN1MAPT | |
| SCHEMBL9879630 | 0.74 | KDM4E (0.60) | MAPTPOLBCYP3A4CYP2C9CYP2C19 | |
| SCHEMBL9619763 | 0.73 | KDM4E (0.38) | CA2CA9CYP3A4CYP2C9CYP2C19 | |
| SCHEMBL7192499 | 0.72 | CAPN1 (0.38) | CAPN1 | |
| Iodide SCHEMBL6795260 | 0.72 | CAPN1 (0.38) | CAPN1 | |
| SCHEMBL13535125 | 0.71 | PTGS1 (0.62) | MAPTPOLBCYP3A4CYP2C9SMN1; SMN2 | |
| SCHEMBL7188174 | 0.70 | EDNRA (0.42) | CA9MAPTTDP1ALDH1A1TP53 | |
| SCHEMBL2351157 | 0.66 | HSD11B1 (0.66) | CA2CA9HSD11B1CYP3A4CYP2C9 | |
| SCHEMBL7088707 | 0.65 | CAPN1 (0.59) | CA2CA9HSD11B1CAPN1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1343774-A1 | 1,1-DIOXO-2H-1, 2-BENZOTHIAZINE-3-CARBOXAMIDE DERIVATIVES, METHOD FOR PREPARING SAME AND PHARMACEUTICAL COMPOSITIONS COMPRISING SAME | Les Laboratoires Servier (FR) | 2003-09-17 | — | — | EP | disclosed |
| WO-2002050049-A1 | 1,1-DIOXO-2H-1, 2-BENZOTHIAZINE-3-CARBOXAMIDE DERIVATIVES, METHOD FOR PREPARING SAME AND PHARMACEUTICAL COMPOSITIONS COMPRISING SAME | LES LABORATOIRES SERVIER (FR) | 2002-06-27 | — | — | WO | disclosed |