Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EDNRA | P25101 | 1/20 | 0.42 |
| ▸ | TTR | P02766 | 2/20 | 0.38 |
| ▸ | RBP4 | P02753 | 3/20 | 0.37 |
| ▸ | ELANE | P08246 | 1/20 | 0.34 |
| ▸ | TP53 | P04637 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.34 |
| ▸ | CA12 | O43570 | 1/20 | 0.34 |
| ▸ | CA1 | P00915 | 1/20 | 0.34 |
| ▸ | CA9 | Q16790 | 1/20 | 0.34 |
| ▸ | HTR1A | P08908 | 1/20 | 0.34 |
| ▸ | DRD2 | P14416 | 1/20 | 0.34 |
| ▸ | HTR2A | P28223 | 1/20 | 0.34 |
| ▸ | HTR7 | P34969 | 1/20 | 0.34 |
| ▸ | HTR6 | P50406 | 1/20 | 0.34 |
| ▸ | SLC22A12 | Q96S37 | 1/20 | 0.33 |
| ▸ | CFTR | P13569 | 2/20 | 0.33 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.33 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7974836 | 0.85 | RBP4 (0.41) | EDNRARBP4ELANETP53MAPT | |
| SCHEMBL7091506 | 0.70 | CA2 (0.42) | TP53MAPTCA9TDP1ALDH1A1 | |
| SCHEMBL6542398 | 0.70 | LMNA (0.60) | EDNRAELANECA12CA1CA9 | |
| SCHEMBL6541145 | 0.68 | EDNRA (0.66) | EDNRATTRRBP4ELANETP53 | |
| SCHEMBL7991423 | 0.67 | HPGD (0.39) | MAPTALDH1A1HPGD | |
| SCHEMBL6542066 | 0.66 | EDNRA (0.63) | EDNRAELANETP53MAPTAKR1C3 | |
| SCHEMBL6542210 | 0.66 | HSD11B1 (0.49) | EDNRARBP4ELANETP53MAPT | |
| SCHEMBL31423139 | 0.60 | AKR1C3 (0.38) | TTRRBP4MAPTAKR1C3TDP1 | |
| SCHEMBL5239668 | 0.60 | AKR1C3 (0.68) | TTRRBP4AKR1C3 | |
| SCHEMBL11701961 | 0.60 | CA2 (0.41) | MAPTCA9TDP1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1289558-A2 | COMBINATIONS OF AN ENDOTHELIN RECEPTOR ANTAGONIST AND AN ANTIEPILEPTIC COMPOUND HAVING PAIN ALLEVIATING PROPERTIES OR ANALGESIC | WARNER-LAMBERT COMPANY LLC (US) | 2003-03-12 | — | — | EP | claimed |
| WO-2001091736-A2 | COMBINATIONS OF AN ENDOTHELIN RECEPTOR ANTAGONIST AND AN ANTIEPILEPTIC COMPOUND HAVING PAIN ALLEVIATING PROPERTIES OR ANALGESIC | WARNER-LAMBERT COMPANY (US) | 2001-12-06 | — | — | WO | claimed |