Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AHR | P35869 | 3/20 | 0.47 |
| ▸ | NR4A2 | P43354 | 2/20 | 0.47 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.47 |
| ▸ | JAK2 | O60674 | 1/20 | 0.42 |
| ▸ | THRA | P10827 | 3/20 | 0.42 |
| ▸ | THRB | P10828 | 3/20 | 0.42 |
| ▸ | PRKCQ | Q04759 | 2/20 | 0.42 |
| ▸ | KDR | P35968 | 1/20 | 0.42 |
| ▸ | CSNK2A1 | P68400 | 1/20 | 0.40 |
| ▸ | LTA4H | P09960 | 2/20 | 0.40 |
| ▸ | MAOA | P21397 | 1/20 | 0.40 |
| ▸ | F7 | P08709 | 1/20 | 0.40 |
| ▸ | F3 | P13726 | 1/20 | 0.40 |
| ▸ | USP2 | O75604 | 1/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.40 |
| ▸ | RAD51 | Q06609 | 1/20 | 0.40 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.40 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.39 |
| ▸ | F2 | P00734 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22646562 | 0.83 | THRA (0.53) | AHRNR4A2CYP2A6JAK2THRA | |
| SCHEMBL7091793 | 0.83 | THRA (0.55) | AHRNR4A2CYP2A6JAK2THRA | |
| SCHEMBL7085833 | 0.80 | CYP2A6 (0.41) | AHRNR4A2CYP2A6JAK2THRA | |
| SCHEMBL7085719 | 0.80 | THRA (0.55) | AHRNR4A2CYP2A6JAK2THRA | |
| SCHEMBL8869295 | 0.77 | AHR (0.63) | AHRNR4A2CYP2A6KDRCSNK2A1 | |
| SCHEMBL25462527 | 0.72 | AHR (0.50) | AHRNR4A2CYP2A6LTA4HMAOA | |
| SCHEMBL2426021 | 0.72 | AHR (0.55) | AHRNR4A2CYP2A6LTA4HMAOA | |
| SCHEMBL3483906 | 0.72 | AHR (0.44) | AHRNR4A2CYP2A6JAK2THRA | |
| SCHEMBL7088630 | 0.72 | THRA (0.47) | THRATHRBKDRNPSR1 | |
| SCHEMBL443361 | 0.71 | NPC1 (0.55) | AHRNR4A2CYP2A6PRKCQLTA4H |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1268422-A1 | INDOLES FOR TREATING DISEASES THAT CAN BE TREATED USING THYROID HORMONES | Bayer Aktiengesellschaft (DE) | 2003-01-02 | — | — | EP | disclosed |
| WO-2001070687-A1 | INDOLES FOR TREATING DISEASES THAT CAN BE TREATED USING THYROID HORMONES | BAYER AKTIENGESELLSCHAFT (DE) | 2001-09-27 | — | — | WO | disclosed |