Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | THRA | P10827 | 3/20 | 0.55 |
| ▸ | THRB | P10828 | 3/20 | 0.55 |
| ▸ | KDR | P35968 | 1/20 | 0.44 |
| ▸ | MAOA | P21397 | 2/20 | 0.42 |
| ▸ | PRKCQ | Q04759 | 2/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | JAK2 | O60674 | 1/20 | 0.39 |
| ▸ | LTA4H | P09960 | 2/20 | 0.39 |
| ▸ | AHR | P35869 | 3/20 | 0.39 |
| ▸ | NR4A2 | P43354 | 2/20 | 0.39 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.39 |
| ▸ | F7 | P08709 | 1/20 | 0.39 |
| ▸ | F3 | P13726 | 1/20 | 0.39 |
| ▸ | USP2 | O75604 | 1/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.39 |
| ▸ | RAD51 | Q06609 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7091630 | 0.83 | AHR (0.47) | THRATHRBKDRMAOAPRKCQ | |
| SCHEMBL22646562 | 0.82 | THRA (0.53) | THRATHRBKDRMAOAPRKCQ | |
| SCHEMBL7084821 | 0.79 | THRA (0.53) | THRATHRBKDRMAOAPRKCQ | |
| SCHEMBL7085719 | 0.78 | THRA (0.55) | THRATHRBKDRMAOAPRKCQ | |
| SCHEMBL2999317 | 0.76 | ALDH1A1 (0.50) | MAOAMEN1POLBMAPK1KMT2A | |
| SCHEMBL7082348 | 0.76 | THRA (0.55) | THRATHRBKDRNPSR1 | |
| SCHEMBL2534386 | 0.76 | MAOA (0.47) | THRATHRBKDRMAOAMEN1 | |
| SCHEMBL3000872 | 0.74 | ALDH1A1 (0.54) | MAOAMEN1POLBMAPK1KMT2A | |
| SCHEMBL2535677 | 0.74 | NOTUM (0.51) | THRATHRBMAOAPRKCQMEN1 | |
| SCHEMBL10804584 | 0.73 | ALDH1A1 (0.57) | MAOAMEN1POLBMAPK1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1268422-A1 | INDOLES FOR TREATING DISEASES THAT CAN BE TREATED USING THYROID HORMONES | Bayer Aktiengesellschaft (DE) | 2003-01-02 | — | — | EP | disclosed |
| WO-2001070687-A1 | INDOLES FOR TREATING DISEASES THAT CAN BE TREATED USING THYROID HORMONES | BAYER AKTIENGESELLSCHAFT (DE) | 2001-09-27 | — | — | WO | disclosed |