Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGES | O14684 | 1/20 | 0.45 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | RAB9A | P51151 | 2/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | PPARA | Q07869 | 2/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.41 |
| ▸ | NPC1 | O15118 | 2/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.41 |
| ▸ | PARP1 | P09874 | 2/20 | 0.41 |
| ▸ | TSHR | P16473 | 2/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.41 |
| ▸ | MEN1 | O00255 | 2/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.41 |
| ▸ | NPY1R | P25929 | 1/20 | 0.41 |
| ▸ | ACKR3 | P25106 | 2/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | SOAT2 | O75908 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4874205 | 0.94 | ACKR3 (0.42) | PTGESLMNARAB9AKDM4EALDH1A1 | |
| SCHEMBL4876175 | 0.91 | ACKR3 (0.43) | LMNARAB9AALDH1A1MAPTKMT2A | |
| SCHEMBL4866709 | 0.87 | PARP1 (0.43) | RAB9AMAPTPPARAKMT2ANPC1 | |
| SCHEMBL4866667 | 0.81 | LMNA (0.45) | PTGESLMNAKDM4EALDH1A1KMT2A | |
| SCHEMBL7085049 | 0.80 | EPHX2 (0.38) | LMNARAB9AALDH1A1MAPTKMT2A | |
| SCHEMBL7091821 | 0.79 | PLA2G2A (0.41) | LMNAPARP1L3MBTL1SOAT2SOAT1 | |
| SCHEMBL4873285 | 0.77 | PARP1 (0.38) | LMNARAB9AKMT2APARP1SOAT2 | |
| SCHEMBL4863336 | 0.76 | NR1H4 (0.42) | LMNARAB9AMAPTPPARANPC1 | |
| SCHEMBL4875116 | 0.75 | ADAMTS5 (0.43) | LMNAKMT2AMEN1L3MBTL1 | |
| SCHEMBL4872747 | 0.75 | MAPT (0.39) | LMNAALDH1A1MAPTKMT2ASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1289965-A1 | SUBSTITUTED 1-AMINOALKYL-LACTAMS AND THEIR USE AS MUSCARINIC RECEPTOR ANTAGONISTS | F. HOFFMANN-LA ROCHE AG (CH) | 2003-03-12 | — | — | EP | disclosed |
| WO-2001090081-A1 | SUBSTITUTED 1-AMINOALKYL-LACTAMS AND THEIR USE AS MUSCARINIC RECEPTOR ANTAGONISTS | F. HOFFMANN-LA ROCHE AG (CH) | 2001-11-29 | — | — | WO | disclosed |