Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPR119 | Q8TDV5 | 9/20 | 0.48 |
| ▸ | ITGB3 | P05106 | 5/20 | 0.45 |
| ▸ | ITGAV | P06756 | 4/20 | 0.45 |
| ▸ | ABL1 | P00519 | 1/20 | 0.42 |
| ▸ | RIN1 | Q13671 | 1/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | PKM | P14618 | 1/20 | 0.42 |
| ▸ | ITGA2B | P08514 | 2/20 | 0.42 |
| ▸ | ITGB1 | P05556 | 1/20 | 0.42 |
| ▸ | ITGB5 | P18084 | 1/20 | 0.42 |
| ▸ | CNR2 | P34972 | 1/20 | 0.40 |
| ▸ | NAMPT | P43490 | 1/20 | 0.40 |
| ▸ | PDK1 | Q15118 | 1/20 | 0.40 |
| ▸ | PDK2 | Q15119 | 1/20 | 0.40 |
| ▸ | PDK3 | Q15120 | 1/20 | 0.40 |
| ▸ | PDK4 | Q16654 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5492684 | 0.86 | ITGB3 (0.50) | ITGB3ITGAVITGA2BITGB1ITGB5 | |
| SCHEMBL7037287 | 0.75 | ITGB3 (0.56) | ITGB3ITGAVITGA2BITGB1ITGB5 | |
| SCHEMBL6958161 | 0.71 | ITGB3 (0.78) | ITGB3ITGAVITGA2B | |
| SCHEMBL6958164 | 0.71 | ITGB3 (0.78) | ITGB3ITGAVITGA2B | |
| SCHEMBL6676238 | 0.71 | ITGB3 (0.78) | ITGB3ITGAVITGA2B | |
| SCHEMBL6641318 | 0.70 | ITGB3 (0.63) | ITGB3ITGAVITGA2BITGB1ITGB5 | |
| SCHEMBL9544216 | 0.70 | NAMPT (0.52) | GPR119KDM4EPKMNAMPT | |
| SCHEMBL9544207 | 0.70 | NAMPT (0.52) | GPR119KDM4EPKMNAMPT | |
| SCHEMBL11677942 | 0.70 | MTNR1A (0.60) | ITGB3ITGAVITGA2BITGB1ITGB5 | |
| SCHEMBL6643325 | 0.70 | ITGB3 (0.53) | ITGB3ITGAVITGA2BITGB1ITGB5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0910563-B1 | INTEGRIN RECEPTOR ANTAGONISTS | SMITHKLINE BEECHAM CORP (US) | 2003-05-02 | — | — | EP | disclosed |
| US-6008213-A | A INHIBITOR OF VITRONECTIN RECEPTOR AND FIBRINOGEN RECEPTOR; USEFUL FOR INHIBITING PLATELET AGGREGATION AND OSTEOPOROSIS | SMITHKLINE BEECHAM CORPORATION (US) | 1999-12-28 | — | — | US | disclosed |