SCHEMBL7092030

SCHEMBL7092030

C[C](C)CCCC1OCCc2cc(Br)ccc21

nearest known ligand 0.39

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
MAPT P10636 1/20 0.39
HTT P42858 1/20 0.39
HTR1D P28221 8/20 0.37
HTR2A P28223 6/20 0.36
DRD2 P14416 5/20 0.36
HTR1A P08908 3/20 0.36
DRD4 P21917 2/20 0.36
HTR1B P28222 2/20 0.36
THRB P10828 1/20 0.35
MAOB P27338 2/20 0.33
GAA P10253 1/20 0.33
L3MBTL1 Q9Y468 1/20 0.33
SLC6A4 P31645 2/20 0.33
SLC6A2 P23975 1/20 0.33
HTR2C P28335 1/20 0.33
ALDH1A1 P00352 1/20 0.32
CYP1A2 P05177 1/20 0.32
CYP2D6 P10635 1/20 0.32
CYP2C19 P33261 1/20 0.32
SRD5A1 P18405 1/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL28745705 1.00 MAPT (0.39) MAPTHTTHTR1DHTR2ADRD2
SCHEMBL8549512 0.83 MAPT (0.38) MAPTHTTHTR1DHTR2ADRD2
SCHEMBL5088620 0.82 PNMT (0.41) MAPTHTTHTR1DHTR2ADRD2
SCHEMBL5090707 0.82 PNMT (0.41) MAPTHTTHTR1DHTR2ADRD2
SCHEMBL20718641 0.79 MAPT (0.41) MAPTHTTHTR2ADRD2HTR1A
SCHEMBL7092032 0.78 MAPT (0.38) MAPTHTTHTR1DHTR2ADRD2
SCHEMBL20699974 0.76 DRD1 (0.49) MAPTHTTHTR1DHTR2ADRD2
SCHEMBL20703561 0.75 TAAR1 (0.55) MAPTHTTDRD2HTR1ATHRB
SCHEMBL20700301 0.75 TAAR1 (0.55) MAPTHTTDRD2HTR1ATHRB
SCHEMBL5093605 0.74 MAPT (0.43) MAPTHTTHTR1DHTR1BTHRB

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1345930-A2 PHARMACEUTICAL COMPOUNDS ELI LILLY AND COMPANY (US) 2003-09-24 EP disclosed
WO-2002050067-A2 PHARMACEUTICAL HETEROCYCLIC COMPOUNDS ELI LILLY AND COMPANY (US) 2002-06-27 WO disclosed