Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 4/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
| ▸ | THRB | P10828 | 1/20 | 0.32 |
| ▸ | GAA | P10253 | 1/20 | 0.32 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.32 |
| ▸ | HTR2A | P28223 | 4/20 | 0.32 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.32 |
| ▸ | HTR2C | P28335 | 1/20 | 0.32 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.32 |
| ▸ | SRD5A1 | P18405 | 1/20 | 0.32 |
| ▸ | CAMK2A | Q9UQM7 | 1/20 | 0.32 |
| ▸ | HTR1D | P28221 | 5/20 | 0.31 |
| ▸ | HTR1B | P28222 | 1/20 | 0.31 |
| ▸ | DRD2 | P14416 | 3/20 | 0.31 |
| ▸ | HTR1A | P08908 | 2/20 | 0.31 |
| ▸ | DRD4 | P21917 | 1/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.31 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.31 |
| ▸ | PNMT | P11086 | 1/20 | 0.31 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20718641 | 0.81 | MAPT (0.41) | MAPTHTTTHRBHTR2ASLC6A2 | |
| SCHEMBL5093605 | 0.79 | MAPT (0.43) | MAPTHTTTHRBGAAL3MBTL1 | |
| SCHEMBL5090662 | 0.79 | MAPT (0.43) | MAPTHTTTHRBGAAL3MBTL1 | |
| SCHEMBL7092030 | 0.78 | MAPT (0.39) | MAPTHTTTHRBGAAL3MBTL1 | |
| SCHEMBL28745705 | 0.78 | MAPT (0.39) | MAPTHTTTHRBGAAL3MBTL1 | |
| SCHEMBL5098858 | 0.78 | MAPT (0.41) | MAPTHTTTHRBHTR2ACAMK2A | |
| SCHEMBL5088620 | 0.75 | PNMT (0.41) | MAPTHTTHTR2ASLC6A4CAMK2A | |
| SCHEMBL5090707 | 0.75 | PNMT (0.41) | MAPTHTTHTR2ASLC6A4CAMK2A | |
| SCHEMBL20699974 | 0.75 | DRD1 (0.49) | MAPTHTTHTR2ASLC6A2HTR2C | |
| SCHEMBL20700301 | 0.74 | TAAR1 (0.55) | MAPTHTTTHRBGAAL3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1345930-A2 | PHARMACEUTICAL COMPOUNDS | ELI LILLY AND COMPANY (US) | 2003-09-24 | — | — | EP | disclosed |
| WO-2002050067-A2 | PHARMACEUTICAL HETEROCYCLIC COMPOUNDS | ELI LILLY AND COMPANY (US) | 2002-06-27 | — | — | WO | disclosed |