Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 2/20 | 0.43 |
| ▸ | LMNA | P02545 | 2/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | GRM2 | Q14416 | 2/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
| ▸ | DRD4 | P21917 | 1/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.38 |
| ▸ | SMO | Q99835 | 4/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.35 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6708674 | 0.91 | MAPT (0.52) | MAPTLMNASMN1; SMN2ALDH1A1HTT | |
| SCHEMBL6710973 | 0.90 | MAPT (0.52) | MAPTLMNASMN1; SMN2ALDH1A1HTT | |
| SCHEMBL7092379 | 0.83 | MAPT (0.41) | MAPTLMNASMN1; SMN2ALDH1A1HTT | |
| SCHEMBL6763043 | 0.78 | MAPT (0.53) | MAPTLMNASMN1; SMN2ALDH1A1HTT | |
| SCHEMBL6709628 | 0.73 | MAPT (0.55) | MAPTLMNASMN1; SMN2ALDH1A1HTT | |
| SCHEMBL6710873 | 0.73 | SMN1; SMN2 (0.62) | MAPTLMNASMN1; SMN2ALDH1A1HTT | |
| SCHEMBL6708390 | 0.72 | MAPT (0.52) | MAPTLMNASMN1; SMN2ALDH1A1HTT | |
| SCHEMBL6760871 | 0.70 | HRH4 (0.48) | LMNAALDH1A1SMOKDM4EKMT2A | |
| SCHEMBL6759310 | 0.69 | ALDH1A1 (0.44) | MAPTLMNASMN1; SMN2ALDH1A1HTT | |
| SCHEMBL6708675 | 0.69 | MAPT (0.52) | MAPTLMNASMN1; SMN2ALDH1A1HTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1324999-A1 | NOVEL AMINOPHENYL PIPERAZINE OR AMINOPHENYL PIPERIDINE DERIVATIVES INHIBITING PRENYL TRANSFERASE PROTEINS AND METHODS FOR PREPARING SAME | PIERRE FABRE MEDICAMENT (FR) | 2003-07-09 | — | — | EP | claimed |
| WO-2002030927-A1 | NOVEL AMINOPHENYL PIPERAZINE OR AMINOPHENYL PIPERIDINE DERIVATIVES INHIBITING PRENYL TRANSFERASE PROTEINS AND METHODS FOR PREPARING SAME | PIERRE FABRE MEDICAMENT (FR) | 2002-04-18 | — | — | WO | claimed |