Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 3/20 | 0.42 |
| ▸ | USP2 | O75604 | 2/20 | 0.42 |
| ▸ | GRIN1 | Q05586 | 2/20 | 0.41 |
| ▸ | GRIN2B | Q13224 | 2/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 6/20 | 0.39 |
| ▸ | LMNA | P02545 | 4/20 | 0.39 |
| ▸ | NPC1 | O15118 | 3/20 | 0.39 |
| ▸ | RAB9A | P51151 | 3/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.39 |
| ▸ | CTSZ | Q9UBR2 | 1/20 | 0.37 |
| ▸ | KDM1A | O60341 | 1/20 | 0.37 |
| ▸ | CTNNB1 | P35222 | 2/20 | 0.36 |
| ▸ | TSHR | P16473 | 2/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | VNN1 | O95497 | 1/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.36 |
| ▸ | WNT3A | P56704 | 1/20 | 0.35 |
| ▸ | TP53 | P04637 | 1/20 | 0.35 |
| ▸ | GAA | P10253 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7034957 | 0.86 | KDM4E (0.46) | MAPTUSP2GRIN1GRIN2BSMN1; SMN2 | |
| SCHEMBL7027068 | 0.82 | USP2 (0.42) | MAPTUSP2GRIN1GRIN2BSMN1; SMN2 | |
| SCHEMBL6995893 | 0.79 | KCNH2 (0.40) | GRIN1GRIN2BALDH1A1KDM4EKDM1A | |
| SCHEMBL2961524 | 0.78 | KCNH2 (0.54) | MAPTUSP2GRIN1GRIN2BSMN1; SMN2 | |
| SCHEMBL7028492 | 0.76 | KDM4E (0.43) | MAPTUSP2SMN1; SMN2LMNANPC1 | |
| SCHEMBL5965991 | 0.75 | USP2 (0.44) | MAPTUSP2GRIN1GRIN2BSMN1; SMN2 | |
| SCHEMBL6990334 | 0.75 | HRH2 (0.38) | GRIN1GRIN2BKDM1AKCNH2 | |
| SCHEMBL6992363 | 0.75 | KCNH2 (0.40) | KDM1AKCNH2 | |
| SCHEMBL6987304 | 0.74 | MCHR1 (0.46) | MAPTKCNH2 | |
| SCHEMBL6994724 | 0.74 | HRH2 (0.42) | KDM1AKCNH2L3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1301510-A1 | NEW BISPIDINE COMPOUNDS AND THEIR USE IN THE TREATMENT OF CARDIAC ARRHYTHMIAS | AstraZeneca AB (SE) | 2003-04-16 | — | — | EP | disclosed |
| WO-2002004446-A1 | NEW BISPIDINE COMPOUNDS AND THEIR USE IN THE TREATMENT OF CARDIAC ARRHYTHMIAS | ASTRAZENECA AB (SE) | 2002-01-17 | — | — | WO | disclosed |