Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNH2 | Q12809 | 1/20 | 0.40 |
| ▸ | MMP2 | P08253 | 8/20 | 0.37 |
| ▸ | MMP3 | P08254 | 7/20 | 0.37 |
| ▸ | KDM1A | O60341 | 1/20 | 0.37 |
| ▸ | HRH2 | P25021 | 2/20 | 0.37 |
| ▸ | HRH1 | P35367 | 2/20 | 0.37 |
| ▸ | HRH3 | Q9Y5N1 | 2/20 | 0.37 |
| ▸ | GRIN1 | Q05586 | 2/20 | 0.36 |
| ▸ | GRIN2B | Q13224 | 2/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.35 |
| ▸ | HPGD | P15428 | 1/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6992363 | 0.87 | KCNH2 (0.40) | KCNH2MMP2MMP3KDM1AHRH2 | |
| SCHEMBL6990334 | 0.87 | HRH2 (0.38) | KCNH2MMP2MMP3KDM1AHRH2 | |
| SCHEMBL6994724 | 0.85 | HRH2 (0.42) | KCNH2KDM1AHRH2HRH1HRH3 | |
| SCHEMBL6987304 | 0.84 | MCHR1 (0.46) | KCNH2MMP2HRH3 | |
| SCHEMBL7089730 | 0.82 | KCNA5 (0.36) | KCNH2MMP2MMP3KDM1AGRIN1 | |
| SCHEMBL6995897 | 0.82 | ALDH1A1 (0.36) | KCNH2MMP2MMP3KDM1AHRH2 | |
| SCHEMBL7092543 | 0.79 | MAPT (0.42) | KCNH2KDM1AGRIN1GRIN2BALDH1A1 | |
| SCHEMBL6737490 | 0.74 | KCNH2 (0.41) | KCNH2MMP2MMP3KDM1AHRH2 | |
| SCHEMBL6740244 | 0.74 | KCNH2 (0.52) | KCNH2KDM1AALDH1A1HPGDKDM4E | |
| SCHEMBL6733200 | 0.73 | KDM1A (0.37) | KCNH2MMP2MMP3KDM1AHRH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1301510-A1 | NEW BISPIDINE COMPOUNDS AND THEIR USE IN THE TREATMENT OF CARDIAC ARRHYTHMIAS | AstraZeneca AB (SE) | 2003-04-16 | — | — | EP | disclosed |
| WO-2002004446-A1 | NEW BISPIDINE COMPOUNDS AND THEIR USE IN THE TREATMENT OF CARDIAC ARRHYTHMIAS | ASTRAZENECA AB (SE) | 2002-01-17 | — | — | WO | disclosed |