Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD3 | P35462 | 2/20 | 0.54 |
| ▸ | HTR1A | P08908 | 1/20 | 0.46 |
| ▸ | HTR2A | P28223 | 8/20 | 0.44 |
| ▸ | HTR2C | P28335 | 7/20 | 0.44 |
| ▸ | HRH3 | Q9Y5N1 | 7/20 | 0.44 |
| ▸ | HTR2B | P41595 | 6/20 | 0.44 |
| ▸ | SIGMAR1 | Q99720 | 3/20 | 0.44 |
| ▸ | HRH1 | P35367 | 2/20 | 0.42 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.42 |
| ▸ | DRD2 | P14416 | 1/20 | 0.42 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.42 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.42 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.42 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.42 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.42 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.42 |
| ▸ | MTOR | P42345 | 1/20 | 0.42 |
| ▸ | HTT | P42858 | 1/20 | 0.42 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.42 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31808827 | 0.84 | DRD3 (0.54) | DRD3HTR1AHTR2AHTR2CHRH3 | |
| SCHEMBL2248107 | 0.84 | DRD3 (0.54) | DRD3HTR1AHTR2AHTR2CHRH3 | |
| SCHEMBL8485673 | 0.84 | DRD3 (0.42) | DRD3HTR1AHTR2AHTR2CSIGMAR1 | |
| SCHEMBL27534166 | 0.80 | DRD3 (0.50) | DRD3HTR1AHTR2AHTR2CHRH3 | |
| SCHEMBL14614546 | 0.80 | DRD3 (0.50) | DRD3HTR1AHTR2AHTR2CHRH3 | |
| Bromide SCHEMBL29349994 | 0.80 | HTR1A (0.56) | DRD3HTR1ACHRM1DRD2 | |
| Hydrochloric Acid SCHEMBL10462146 | 0.77 | SIGMAR1 (0.50) | DRD3HTR2AHTR2CHRH3HTR2B | |
| SCHEMBL20012253 | 0.77 | HTR2A (0.49) | DRD3HTR1AHTR2AHTR2CHRH3 | |
| SCHEMBL12125958 | 0.77 | DRD3 (0.57) | DRD3HTR1AHTR2AHTR2CHRH3 | |
| SCHEMBL14626044 | 0.75 | DRD3 (0.46) | DRD3HTR1AHTR2AHTR2CHRH3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1069132-B1 | Bicyclic derivatives of amino-pyrazinones, process of preparation and pharmaceutical compositions comprising them | SERVIER LAB (FR) | 2003-10-01 | — | — | EP | disclosed |
| EP-1069132-A1 | Bicyclic derivatives of amino-pyrazinones, process of preparation and pharmaceutical compositions comprising them | ADIR ET COMPAGNIE (FR) | 2001-01-17 | — | — | EP | disclosed |