Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PGR | P06401 | 20/20 | 1.00 |
| ▸ | NR3C1 | P04150 | 15/20 | 1.00 |
| ▸ | AR | P10275 | 13/20 | 1.00 |
| ▸ | NR3C2 | P08235 | 11/20 | 0.86 |
| ▸ | ESR1 | P03372 | 10/20 | 0.86 |
| ▸ | ESR2 | Q92731 | 10/20 | 0.86 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6650996 | 0.92 | PGR (1.00) | PGRNR3C1ARNR3C2ESR1 | |
| SCHEMBL6648377 | 0.87 | PGR (1.00) | PGRNR3C1ARNR3C2ESR1 | |
| SCHEMBL6294460 | 0.87 | NR3C1 (0.81) | PGRNR3C1ARNR3C2ESR1 | |
| SCHEMBL8146749 | 0.86 | PGR (0.82) | PGRNR3C1ARNR3C2ESR1 | |
| SCHEMBL6295018 | 0.84 | PGR (0.74) | PGRNR3C1ARNR3C2ESR1 | |
| SCHEMBL4167703 | 0.84 | NR3C1 (1.00) | PGRNR3C1ARNR3C2ESR1 | |
| SCHEMBL6290341 | 0.84 | NR3C1 (0.74) | PGRNR3C1ARNR3C2ESR1 | |
| SCHEMBL8015600 | 0.84 | PGR (1.00) | PGRNR3C1ARNR3C2ESR1 | |
| SCHEMBL6648200 | 0.83 | PGR (1.00) | PGRNR3C1ARNR3C2ESR1 | |
| SCHEMBL6650300 | 0.83 | PGR (1.00) | PGRNR3C1ARNR3C2ESR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1053239-B1 | GLUCOCORTICOID-SELECTIVE ANTI-INFLAMMATORY AGENTS | ABBOTT LAB (US) | 2003-01-08 | — | — | EP | claimed |
| EP-1299392-A2 | GLUCOCORTIOCOID-SELECTIVE ANTIINFLAMMATORY AGENTS | Abbott Laboratories (US) | 2003-04-09 | — | — | EP | disclosed |
| WO-2002002565-A2 | GLUCOCORTIOCOID-SELECTIVE ANTIINFLAMMATORY AGENTS | ABBOTT LABORATORIES (US) | 2002-01-10 | — | — | WO | disclosed |