Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GABRG2 | P18507 | 17/20 | 0.55 |
| ▸ | GABRB3 | P28472 | 17/20 | 0.55 |
| ▸ | GABRA3 | P34903 | 17/20 | 0.55 |
| ▸ | GABRA1 | P14867 | 14/20 | 0.55 |
| ▸ | GABRA2 | P47869 | 11/20 | 0.55 |
| ▸ | GABRA5 | P31644 | 8/20 | 0.55 |
| ▸ | HSD11B1 | P28845 | 2/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6997828 | 0.81 | GABRA1 (0.41) | GABRG2GABRB3GABRA3GABRA1GABRA2 | |
| SCHEMBL7092981 | 0.81 | GABRG2 (0.72) | GABRG2GABRB3GABRA3GABRA1GABRA2 | |
| SCHEMBL6030276 | 0.78 | GABRG2 (0.68) | GABRG2GABRB3GABRA3GABRA1GABRA2 | |
| SCHEMBL2654038 | 0.76 | GABRG2 (0.68) | GABRG2GABRB3GABRA3GABRA1GABRA2 | |
| SCHEMBL341534 | 0.74 | GABRG2 (0.68) | GABRG2GABRB3GABRA3GABRA1GABRA2 | |
| SCHEMBL342931 | 0.72 | GABRG2 (0.77) | GABRG2GABRB3GABRA3GABRA1GABRA2 | |
| SCHEMBL7093794 | 0.72 | GABRA1 (0.38) | GABRG2GABRB3GABRA3GABRA1GABRA2 | |
| SCHEMBL2652425 | 0.71 | GABRG2 (1.00) | GABRG2GABRB3GABRA3GABRA1GABRA2 | |
| SCHEMBL341232 | 0.70 | GABRG2 (0.82) | GABRG2GABRB3GABRA3GABRA1GABRA2 | |
| SCHEMBL340744 | 0.69 | GABRG2 (1.00) | GABRG2GABRB3GABRA3GABRA1GABRA2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0915875-B1 | SUBSTITUTED TRIAZOLO-PYRIDAZINE DERIVATIVES AS LIGANDS FOR GABA RECEPTORS | MERCK SHARP & DOHME (GB) | 2003-04-09 | — | — | EP | disclosed |