Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GABRA1 | P14867 | 8/20 | 0.38 |
| ▸ | GABRG2 | P18507 | 8/20 | 0.38 |
| ▸ | GABRB3 | P28472 | 8/20 | 0.38 |
| ▸ | GABRA3 | P34903 | 8/20 | 0.38 |
| ▸ | GABRA5 | P31644 | 6/20 | 0.38 |
| ▸ | GABRA2 | P47869 | 6/20 | 0.38 |
| ▸ | HSD11B1 | P28845 | 2/20 | 0.38 |
| ▸ | ADORA3 | P0DMS8 | 3/20 | 0.35 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.34 |
| ▸ | NPC1 | O15118 | 1/20 | 0.34 |
| ▸ | TSHR | P16473 | 1/20 | 0.34 |
| ▸ | RAB9A | P51151 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
| ▸ | THRB | P10828 | 1/20 | 0.33 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7093278 | 0.88 | GABRA1 (0.33) | GABRA1GABRG2GABRB3GABRA3GABRA5 | |
| SCHEMBL7093795 | 0.81 | GABRA1 (0.39) | GABRA1GABRG2GABRB3GABRA3GABRA5 | |
| SCHEMBL340830 | 0.73 | GABRG2 (0.49) | GABRA1GABRG2GABRB3GABRA3GABRA5 | |
| SCHEMBL341429 | 0.73 | GABRA1 (0.41) | GABRA1GABRG2GABRB3GABRA3GABRA5 | |
| SCHEMBL7092977 | 0.72 | GABRG2 (0.55) | GABRA1GABRG2GABRB3GABRA3GABRA5 | |
| SCHEMBL6528911 | 0.71 | GABRA1 (0.41) | GABRA1GABRG2GABRB3GABRA3GABRA5 | |
| SCHEMBL341136 | 0.70 | GABRA1 (0.43) | GABRA1GABRG2GABRB3GABRA3GABRA5 | |
| SCHEMBL7093281 | 0.70 | GABRG2 (0.41) | GABRA1GABRG2GABRB3GABRA3GABRA5 | |
| SCHEMBL6990798 | 0.69 | GABRA1 (0.42) | GABRA1GABRG2GABRB3GABRA3GABRA5 | |
| SCHEMBL342194 | 0.69 | GABRA1 (0.40) | GABRA1GABRG2GABRB3GABRA3GABRA5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0915875-B1 | SUBSTITUTED TRIAZOLO-PYRIDAZINE DERIVATIVES AS LIGANDS FOR GABA RECEPTORS | MERCK SHARP & DOHME (GB) | 2003-04-09 | — | — | EP | disclosed |