Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 6/20 | 0.58 |
| ▸ | RAB9A | P51151 | 6/20 | 0.58 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.58 |
| ▸ | GAA | P10253 | 1/20 | 0.58 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.51 |
| ▸ | MEN1 | O00255 | 3/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.51 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.51 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.51 |
| ▸ | HTT | P42858 | 3/20 | 0.50 |
| ▸ | LMNA | P02545 | 2/20 | 0.50 |
| ▸ | MAPT | P10636 | 1/20 | 0.50 |
| ▸ | CDC25A | P30304 | 1/20 | 0.50 |
| ▸ | CDC25B | P30305 | 1/20 | 0.50 |
| ▸ | CDC25C | P30307 | 1/20 | 0.50 |
| ▸ | PKM | P14618 | 1/20 | 0.50 |
| ▸ | CCR6 | P51684 | 1/20 | 0.49 |
| ▸ | TSHR | P16473 | 1/20 | 0.48 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27830128 | 0.70 | NPC1 (0.57) | NPC1RAB9AKDM4EGAASMN1; SMN2 | |
| SCHEMBL5062627 | 0.69 | KDM4E (0.61) | NPC1RAB9AKDM4EGAASMN1; SMN2 | |
| SCHEMBL4797356 | 0.69 | ALDH1A1 (0.40) | NPC1RAB9AKDM4EGAASMN1; SMN2 | |
| SCHEMBL10671618 | 0.69 | SMN1; SMN2 (0.61) | NPC1RAB9AKDM4ESMN1; SMN2ALDH1A1 | |
| SCHEMBL5912479 | 0.69 | NPC1 (0.55) | NPC1RAB9AKDM4ESMN1; SMN2ALDH1A1 | |
| SCHEMBL1412848 | 0.68 | KDM4E (0.59) | NPC1RAB9AKDM4EGAASMN1; SMN2 | |
| SCHEMBL31312521 | 0.68 | NPC1 (0.63) | NPC1RAB9AKDM4EGAASMN1; SMN2 | |
| SCHEMBL22728498 | 0.67 | LMNA (0.78) | NPC1RAB9AKDM4EGAASMN1; SMN2 | |
| SCHEMBL1452104 | 0.67 | RAB9A (0.71) | NPC1RAB9ASMN1; SMN2ALDH1A1MEN1 | |
| SCHEMBL3715797 | 0.67 | KDM4E (0.57) | NPC1RAB9AKDM4EGAASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2003082875-A2 | NOVEL PODOPHYLLOTOXIN DERIVATIVES, THE PRODUCTION THEREOF AND THE USE OF THE SAME IN THERAPEUTICS | POTIER PIERRE (FR) | 2003-10-09 | — | — | WO | disclosed |