Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.51 |
| ▸ | HPGD | P15428 | 1/20 | 0.51 |
| ▸ | PTGS2 | P35354 | 3/20 | 0.48 |
| ▸ | MDM2 | Q00987 | 1/20 | 0.44 |
| ▸ | GSK3B | P49841 | 1/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.38 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.38 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.38 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.38 |
| ▸ | SIRT2 | Q8IXJ6 | 1/20 | 0.38 |
| ▸ | SIRT1 | Q96EB6 | 1/20 | 0.38 |
| ▸ | SIRT3 | Q9NTG7 | 1/20 | 0.38 |
| ▸ | SIRT5 | Q9NXA8 | 1/20 | 0.38 |
| ▸ | SMPD3 | Q9NY59 | 1/20 | 0.38 |
| ▸ | XDH | P47989 | 1/20 | 0.38 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7090889 | 0.86 | HSD17B10 (0.66) | HSD17B10ALDH1A1HPGDMDM2POLB | |
| SCHEMBL1573106 | 0.85 | PTGS2 (0.50) | HSD17B10ALDH1A1HPGDPTGS2MDM2 | |
| SCHEMBL7091477 | 0.84 | POLB (0.56) | HSD17B10ALDH1A1HPGDPTGS2MDM2 | |
| SCHEMBL7092828 | 0.81 | ALDH1A1 (0.55) | HSD17B10ALDH1A1HPGDPTGS2MDM2 | |
| SCHEMBL7093919 | 0.81 | ALDH1A1 (0.55) | HSD17B10ALDH1A1HPGDPTGS2MDM2 | |
| SCHEMBL7093922 | 0.80 | ALDH1A1 (0.51) | HSD17B10ALDH1A1HPGDPTGS2MDM2 | |
| SCHEMBL7092623 | 0.79 | PTGS2 (0.60) | HSD17B10ALDH1A1HPGDPTGS2PTGS1 | |
| SCHEMBL11186325 | 0.78 | PTGS2 (0.39) | ALDH1A1PTGS2GSK3BPOLB | |
| SCHEMBL7094140 | 0.77 | ALDH1A1 (0.51) | HSD17B10ALDH1A1HPGDMDM2CYP1A2 | |
| SCHEMBL7090564 | 0.76 | PTGS2 (0.60) | HSD17B10ALDH1A1HPGDPTGS2PTGS1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2003084935-A2 | DIARYL PYRIMIDINONE DERIVATIVES USEFUL FOR THE TREATMENT OF INFLAMMATION AND IMMUNOGOLICAL DISEASES | ORCHID CHEMICALS & PHARMACEUTICALS LTD (IN) | 2003-10-16 | — | — | WO | claimed |
| WO-2003084935-A2 | DIARYL PYRIMIDINONE DERIVATIVES USEFUL FOR THE TREATMENT OF INFLAMMATION AND IMMUNOGOLICAL DISEASES | ORCHID CHEMICALS & PHARMACEUTICALS LTD (IN) | 2003-10-16 | — | — | WO | disclosed |