Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A4 | P31645 | 9/20 | 0.43 |
| ▸ | HRH3 | Q9Y5N1 | 9/20 | 0.43 |
| ▸ | MEN1 | O00255 | 6/20 | 0.35 |
| ▸ | SLC6A2 | P23975 | 2/20 | 0.34 |
| ▸ | CCR5 | P51681 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.33 |
| ▸ | HRH2 | P25021 | 2/20 | 0.33 |
| ▸ | HRH1 | P35367 | 2/20 | 0.33 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.33 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.33 |
| ▸ | CACNA1F | O60840 | 1/20 | 0.33 |
| ▸ | HTR1A | P08908 | 1/20 | 0.33 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.33 |
| ▸ | DRD2 | P14416 | 1/20 | 0.33 |
| ▸ | CNR1 | P21554 | 1/20 | 0.33 |
| ▸ | DRD1 | P21728 | 1/20 | 0.33 |
| ▸ | DRD4 | P21917 | 1/20 | 0.33 |
| ▸ | DRD5 | P21918 | 1/20 | 0.33 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.33 |
| ▸ | HTR1B | P28222 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7245226 | 0.91 | HRH3 (0.41) | SLC6A4HRH3MEN1SLC6A2CCR5 | |
| SCHEMBL6977224 | 0.82 | HRH3 (0.40) | SLC6A4HRH3MEN1SLC6A2KMT2A | |
| SCHEMBL7248290 | 0.81 | HRH3 (0.43) | SLC6A4HRH3MEN1SLC6A2CCR5 | |
| SCHEMBL5965958 | 0.79 | HRH3 (0.37) | SLC6A4HRH3MEN1SLC6A2KMT2A | |
| SCHEMBL5965706 | 0.79 | HRH3 (0.40) | SLC6A4HRH3MEN1KMT2AHRH2 | |
| SCHEMBL5965411 | 0.78 | HRH3 (0.40) | SLC6A4HRH3MEN1KMT2AHRH2 | |
| SCHEMBL6987525 | 0.77 | HRH3 (0.37) | SLC6A4HRH3MEN1KMT2AGRIN1 | |
| SCHEMBL7093343 | 0.77 | HRH3 (0.41) | SLC6A4HRH3MEN1KMT2AGRIN1 | |
| SCHEMBL5965701 | 0.76 | GPR119 (0.42) | SLC6A4HRH3MEN1KMT2A | |
| SCHEMBL7243589 | 0.74 | HRH3 (0.42) | SLC6A4HRH3SLC6A2CCR5HRH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6559162-B2 | Electrophysiological activity | ASTRAZENECA AB (SE) | 2003-05-06 | — | — | US | disclosed |
| US-20020137766-A1 | Azabicyclooctane derivatives useful in the treatment of cardiac arrhythmias | ASTRAZENECA AB (SE) | 2002-09-26 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20020137766-A1 | Azabicyclooctane derivatives useful in the treatment of cardiac arrhythmias | KCNH1, KCNH2, KCNH3 | SLC6A4 4858/4885HRH3 742/4885MEN1 1813/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.