Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 3/20 | 0.52 |
| ▸ | POLB | P06746 | 2/20 | 0.52 |
| ▸ | BRD4 | O60885 | 1/20 | 0.48 |
| ▸ | CREBBP | Q92793 | 1/20 | 0.48 |
| ▸ | CYP17A1 | P05093 | 2/20 | 0.48 |
| ▸ | PSMB8 | P28062 | 1/20 | 0.46 |
| ▸ | MAPT | P10636 | 1/20 | 0.46 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.46 |
| ▸ | FFAR4 | Q5NUL3 | 1/20 | 0.45 |
| ▸ | NAMPT | P43490 | 1/20 | 0.43 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.43 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.43 |
| ▸ | KIT | P10721 | 1/20 | 0.43 |
| ▸ | KDR | P35968 | 1/20 | 0.43 |
| ▸ | FLT3 | P36888 | 1/20 | 0.43 |
| ▸ | PPARG | P37231 | 1/20 | 0.43 |
| ▸ | PPARA | Q07869 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | GAA | P10253 | 1/20 | 0.42 |
| ▸ | F2 | P00734 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11900140 | 0.83 | LMNA (0.52) | LMNAPOLBCYP17A1FFAR4RXFP1 | |
| SCHEMBL7081238 | 0.81 | RXFP1 (0.57) | LMNAPOLBNAMPTRXFP1GAA | |
| SCHEMBL3790541 | 0.81 | CYP17A1 (0.50) | BRD4CREBBPCYP17A1PSMB8NAMPT | |
| SCHEMBL28456035 | 0.81 | P2RY14 (0.42) | LMNAPOLBBRD4CYP17A1PSMB8 | |
| SCHEMBL15139200 | 0.80 | CYP17A1 (0.52) | BRD4CREBBPCYP17A1PSMB8NAMPT | |
| SCHEMBL5964783 | 0.80 | ALDH1A1 (0.51) | LMNAPOLBMAPTTDP1FFAR4 | |
| SCHEMBL18570243 | 0.79 | CYP17A1 (0.61) | CYP17A1PSMB8MAPTNAMPTMAP4K4 | |
| SCHEMBL28609210 | 0.79 | LMNA (0.46) | LMNAPOLBMAPTTDP1RXFP1 | |
| SCHEMBL20865536 | 0.79 | CYP17A1 (0.68) | BRD4CREBBPCYP17A1PSMB8NAMPT | |
| SCHEMBL20847486 | 0.78 | CYP17A1 (0.51) | BRD4CREBBPCYP17A1PSMB8NAMPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1370558-A1 | PIPERAZINE- AND PIPERIDINE-DERIVATIVES AS MELANOCORTIN RECEPTOR AGONISTS | ELI LILLY AND COMPANY (US) | 2003-12-17 | — | — | EP | disclosed |
| WO-2002059117-A1 | PIPERAZINE- AND PIPERIDINE-DERIVATIVES AS MELANOCORTIN RECEPTOR AGONISTS | ELI LILLY AND COMPANY (US) | 2002-08-01 | — | — | WO | disclosed |