Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHEK1 | O14757 | 4/20 | 0.44 |
| ▸ | SMYD2 | Q9NRG4 | 7/20 | 0.43 |
| ▸ | PIM1 | P11309 | 2/20 | 0.42 |
| ▸ | KDR | P35968 | 4/20 | 0.42 |
| ▸ | PDGFRB | P09619 | 3/20 | 0.42 |
| ▸ | FGFR1 | P11362 | 2/20 | 0.42 |
| ▸ | TLK2 | Q86UE8 | 1/20 | 0.42 |
| ▸ | RAD52 | P43351 | 2/20 | 0.38 |
| ▸ | ALK | Q9UM73 | 1/20 | 0.38 |
| ▸ | GSK3A | P49840 | 1/20 | 0.38 |
| ▸ | GSK3B | P49841 | 1/20 | 0.38 |
| ▸ | CDK5 | Q00535 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | CDK5R1 | Q15078 | 1/20 | 0.38 |
| ▸ | PRKAA2 | P54646 | 1/20 | 0.38 |
| ▸ | PRKAA1 | Q13131 | 1/20 | 0.38 |
| ▸ | KIT | P10721 | 1/20 | 0.38 |
| ▸ | PIM2 | Q9P1W9 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6324172 | 0.92 | SMYD2 (0.47) | CHEK1SMYD2PIM1KDRPDGFRB | |
| SCHEMBL7095986 | 0.84 | CHEK1 (0.50) | CHEK1PIM1KDRPDGFRBFGFR1 | |
| SCHEMBL7004752 | 0.83 | PDGFRB (0.53) | CHEK1PIM1KDRPDGFRBFGFR1 | |
| SCHEMBL6324772 | 0.82 | FLT1 (0.47) | CHEK1KDRPDGFRBFGFR1TLK2 | |
| SCHEMBL6326926 | 0.81 | PDGFRB (0.49) | CHEK1PIM1KDRPDGFRBFGFR1 | |
| SCHEMBL6328657 | 0.79 | PDGFRB (0.46) | CHEK1SMYD2PIM1KDRPDGFRB | |
| SCHEMBL6321260 | 0.77 | ALK (0.39) | KDRPDGFRBFGFR1ALKKMT2A | |
| SCHEMBL143687 | 0.75 | SRC (0.49) | KDRPDGFRBFGFR1TLK2ALK | |
| SCHEMBL143213 | 0.74 | SRC (0.48) | PIM1KDRPDGFRBFGFR1TLK2 | |
| SCHEMBL6321236 | 0.74 | PDGFRB (0.51) | CHEK1PIM1KDRPDGFRBFGFR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1349852-A2 | 4-(HETERO)ARYL SUBSTITUTED INDOLINONES | Sugen, Inc. (US) | 2003-10-08 | — | — | EP | disclosed |
| WO-2002055517-A2 | 4-(HETERO)ARYL SUBSTITUTED INDOLINONES | CUI JINGRONG (US) | 2002-07-18 | — | — | WO | disclosed |