Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDGFRB | P09619 | 3/20 | 0.53 |
| ▸ | KDR | P35968 | 3/20 | 0.53 |
| ▸ | FLT3 | P36888 | 2/20 | 0.53 |
| ▸ | AURKB | Q96GD4 | 2/20 | 0.53 |
| ▸ | MET | P08581 | 1/20 | 0.53 |
| ▸ | CHEK1 | O14757 | 6/20 | 0.49 |
| ▸ | AURKA | O14965 | 1/20 | 0.48 |
| ▸ | LCK | P06239 | 1/20 | 0.48 |
| ▸ | KIT | P10721 | 1/20 | 0.48 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.48 |
| ▸ | FGFR1 | P11362 | 2/20 | 0.47 |
| ▸ | TLK2 | Q86UE8 | 1/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.47 |
| ▸ | RAD52 | P43351 | 2/20 | 0.46 |
| ▸ | MITF | O75030 | 2/20 | 0.46 |
| ▸ | PIM1 | P11309 | 1/20 | 0.46 |
| ▸ | PAX8 | Q06710 | 1/20 | 0.45 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
| ▸ | HTR3A | P46098 | 1/20 | 0.41 |
| ▸ | GSK3A | P49840 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7095986 | 0.91 | CHEK1 (0.50) | PDGFRBKDRFLT3AURKBMET | |
| SCHEMBL6324172 | 0.87 | SMYD2 (0.47) | PDGFRBKDRCHEK1FGFR1TLK2 | |
| SCHEMBL6326926 | 0.86 | PDGFRB (0.49) | PDGFRBKDRFLT3AURKBCHEK1 | |
| SCHEMBL7094511 | 0.83 | CHEK1 (0.44) | PDGFRBKDRCHEK1KITFGFR1 | |
| SCHEMBL6402187 | 0.81 | KDR (0.63) | PDGFRBKDRFLT3AURKBMET | |
| SCHEMBL6402191 | 0.81 | KDR (0.63) | PDGFRBKDRFLT3AURKBMET | |
| SCHEMBL6320448 | 0.81 | RET (0.48) | PDGFRBKDRFLT3AURKBCHEK1 | |
| SCHEMBL6320444 | 0.81 | RET (0.48) | PDGFRBKDRFLT3AURKBCHEK1 | |
| SCHEMBL7094064 | 0.78 | DGAT2 (0.43) | PDGFRBKDRCHEK1FGFR1 | |
| SCHEMBL7094200 | 0.77 | ALK (0.39) | PDGFRBKDRFLT3AURKBCHEK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1349852-A2 | 4-(HETERO)ARYL SUBSTITUTED INDOLINONES | Sugen, Inc. (US) | 2003-10-08 | — | — | EP | disclosed |
| WO-2002055517-A2 | 4-(HETERO)ARYL SUBSTITUTED INDOLINONES | CUI JINGRONG (US) | 2002-07-18 | — | — | WO | disclosed |