Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMYD2 | Q9NRG4 | 5/20 | 0.47 |
| ▸ | CHEK1 | O14757 | 3/20 | 0.47 |
| ▸ | PIM1 | P11309 | 1/20 | 0.47 |
| ▸ | PDGFRB | P09619 | 2/20 | 0.45 |
| ▸ | FGFR1 | P11362 | 2/20 | 0.45 |
| ▸ | KDR | P35968 | 2/20 | 0.45 |
| ▸ | TLK2 | Q86UE8 | 1/20 | 0.45 |
| ▸ | HTR2A | P28223 | 2/20 | 0.42 |
| ▸ | HTR2C | P28335 | 2/20 | 0.42 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.42 |
| ▸ | FLT1 | P17948 | 1/20 | 0.42 |
| ▸ | ALK | Q9UM73 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.41 |
| ▸ | RAD52 | P43351 | 2/20 | 0.41 |
| ▸ | GSK3A | P49840 | 1/20 | 0.41 |
| ▸ | GSK3B | P49841 | 1/20 | 0.41 |
| ▸ | CDK5 | Q00535 | 1/20 | 0.41 |
| ▸ | CDK5R1 | Q15078 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7094511 | 0.92 | CHEK1 (0.44) | SMYD2CHEK1PIM1PDGFRBFGFR1 | |
| SCHEMBL7095986 | 0.88 | CHEK1 (0.50) | CHEK1PIM1PDGFRBFGFR1KDR | |
| SCHEMBL7004752 | 0.87 | PDGFRB (0.53) | CHEK1PIM1PDGFRBFGFR1KDR | |
| SCHEMBL6326926 | 0.84 | PDGFRB (0.49) | CHEK1PIM1PDGFRBFGFR1KDR | |
| SCHEMBL6328657 | 0.81 | PDGFRB (0.46) | SMYD2CHEK1PIM1PDGFRBFGFR1 | |
| SCHEMBL6321139 | 0.79 | ALK (0.53) | CHEK1PDGFRBFGFR1KDRTLK2 | |
| SCHEMBL143687 | 0.79 | SRC (0.49) | PDGFRBFGFR1KDRTLK2ALK | |
| SCHEMBL6321236 | 0.76 | PDGFRB (0.51) | CHEK1PIM1PDGFRBFGFR1KDR | |
| SCHEMBL6323517 | 0.76 | L3MBTL3 (0.47) | SMYD2PDGFRBFGFR1KDRFLT1 | |
| SCHEMBL6322548 | 0.76 | KDR (0.46) | PDGFRBFGFR1KDRFLT1ALK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6861418-B2 | 4-aryl substituted indolinones | SUGEN, INC. (US) | 2005-03-01 | — | — | US | disclosed |