Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHEK1 | O14757 | 6/20 | 0.50 |
| ▸ | PDGFRB | P09619 | 3/20 | 0.48 |
| ▸ | KDR | P35968 | 3/20 | 0.48 |
| ▸ | FGFR1 | P11362 | 2/20 | 0.48 |
| ▸ | TLK2 | Q86UE8 | 1/20 | 0.48 |
| ▸ | PIM1 | P11309 | 5/20 | 0.47 |
| ▸ | FLT3 | P36888 | 2/20 | 0.43 |
| ▸ | AURKB | Q96GD4 | 2/20 | 0.43 |
| ▸ | MET | P08581 | 1/20 | 0.43 |
| ▸ | MITF | O75030 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | PIM2 | Q9P1W9 | 4/20 | 0.41 |
| ▸ | ALK | Q9UM73 | 1/20 | 0.40 |
| ▸ | AURKA | O14965 | 1/20 | 0.40 |
| ▸ | LCK | P06239 | 1/20 | 0.40 |
| ▸ | KIT | P10721 | 1/20 | 0.40 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.40 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.40 |
| ▸ | AKT2 | P31751 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7004752 | 0.91 | PDGFRB (0.53) | CHEK1PDGFRBKDRFGFR1TLK2 | |
| SCHEMBL6324172 | 0.88 | SMYD2 (0.47) | CHEK1PDGFRBKDRFGFR1TLK2 | |
| SCHEMBL6326926 | 0.88 | PDGFRB (0.49) | CHEK1PDGFRBKDRFGFR1TLK2 | |
| SCHEMBL7094200 | 0.86 | ALK (0.39) | CHEK1PDGFRBKDRFGFR1FLT3 | |
| SCHEMBL2116627 | 0.85 | KDR (0.61) | CHEK1PDGFRBKDRFGFR1TLK2 | |
| SCHEMBL31672554 | 0.85 | KDR (0.61) | CHEK1PDGFRBKDRFGFR1TLK2 | |
| SCHEMBL13755246 | 0.85 | KDR (0.61) | CHEK1PDGFRBKDRFGFR1TLK2 | |
| SCHEMBL7094511 | 0.84 | CHEK1 (0.44) | CHEK1PDGFRBKDRFGFR1TLK2 | |
| SCHEMBL6884531 | 0.81 | PDGFRB (0.63) | CHEK1PDGFRBKDRFGFR1TLK2 | |
| SCHEMBL6884535 | 0.81 | PDGFRB (0.63) | CHEK1PDGFRBKDRFGFR1TLK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1349852-A2 | 4-(HETERO)ARYL SUBSTITUTED INDOLINONES | Sugen, Inc. (US) | 2003-10-08 | — | — | EP | disclosed |
| WO-2002055517-A2 | 4-(HETERO)ARYL SUBSTITUTED INDOLINONES | CUI JINGRONG (US) | 2002-07-18 | — | — | WO | disclosed |