Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SYK | P43405 | 1/20 | 0.53 |
| ▸ | SRC | P12931 | 2/20 | 0.49 |
| ▸ | LTA4H | P09960 | 1/20 | 0.49 |
| ▸ | HTR2C | P28335 | 2/20 | 0.47 |
| ▸ | HTR2B | P41595 | 2/20 | 0.47 |
| ▸ | TSHR | P16473 | 2/20 | 0.47 |
| ▸ | POLB | P06746 | 1/20 | 0.47 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.47 |
| ▸ | ADORA2A | P29274 | 2/20 | 0.47 |
| ▸ | DRD2 | P14416 | 1/20 | 0.45 |
| ▸ | DRD3 | P35462 | 1/20 | 0.45 |
| ▸ | MAP3K11 | Q16584 | 1/20 | 0.45 |
| ▸ | KIT | P10721 | 1/20 | 0.45 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.45 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7096353 | 0.89 | LTA4H (0.62) | LTA4HHTR2CHTR2BPOLBADORA2A | |
| SCHEMBL7100163 | 0.88 | LTA4H (0.61) | LTA4HHTR2CHTR2BPOLBADORA2A | |
| SCHEMBL7172012 | 0.86 | MAP3K11 (0.53) | LTA4HDRD2DRD3MAP3K11KIT | |
| SCHEMBL8661974 | 0.81 | EHMT2 (0.48) | SRCLTA4HDRD2DRD3 | |
| SCHEMBL21676385 | 0.80 | SYK (0.55) | SYKHTR2CHTR2BPOLBADORA2A | |
| SCHEMBL6433993 | 0.80 | SRC (0.56) | SRCTSHRCYP2D6KITCHEK1 | |
| SCHEMBL4374046 | 0.79 | SRC (0.54) | SYKSRCKIT | |
| SCHEMBL4125652 | 0.79 | LTA4H (0.78) | LTA4HDRD2DRD3 | |
| SCHEMBL13849354 | 0.77 | SYK (0.64) | SYKSRCHTR2CHTR2BTSHR | |
| SCHEMBL12845584 | 0.77 | SYK (0.64) | SYKSRCHTR2CHTR2BTSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1309551-A1 | INDOLINE DERIVATIVES AS 5HT2C ANTAGONISTS | SMITHKLINE BEECHAM PLC (GB) | 2003-05-14 | — | — | EP | disclosed |
| WO-2002014273-A1 | INDOLINE DERIVATIVES AS 5HT2C ANTAGONISTS | SMITHKLINE BEECHAM P.L.C. (GB) | 2002-02-21 | — | — | WO | disclosed |