Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LTA4H | P09960 | 2/20 | 0.62 |
| ▸ | POLB | P06746 | 1/20 | 0.51 |
| ▸ | EHMT2 | Q96KQ7 | 5/20 | 0.51 |
| ▸ | EHMT1 | Q9H9B1 | 4/20 | 0.51 |
| ▸ | DRD2 | P14416 | 1/20 | 0.47 |
| ▸ | DRD3 | P35462 | 1/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.46 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.46 |
| ▸ | HTR2A | P28223 | 1/20 | 0.46 |
| ▸ | HTR2C | P28335 | 1/20 | 0.46 |
| ▸ | HTR2B | P41595 | 1/20 | 0.46 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.44 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7100163 | 0.99 | LTA4H (0.61) | LTA4HPOLBEHMT2EHMT1DRD2 | |
| SCHEMBL7172012 | 0.90 | MAP3K11 (0.53) | LTA4HEHMT2EHMT1DRD2DRD3 | |
| SCHEMBL7095054 | 0.89 | SYK (0.53) | LTA4HPOLBDRD2DRD3HTR2C | |
| SCHEMBL8661974 | 0.84 | EHMT2 (0.48) | LTA4HEHMT2EHMT1DRD2DRD3 | |
| SCHEMBL7100140 | 0.82 | LTA4H (0.62) | LTA4HDRD2DRD3SMN1; SMN2TDP1 | |
| SCHEMBL4378567 | 0.79 | ABCB11 (0.64) | EHMT2EHMT1 | |
| SCHEMBL6431234 | 0.78 | EHMT2 (0.53) | EHMT2EHMT1 | |
| SCHEMBL1748737 | 0.78 | TLR8 (0.60) | LTA4HPOLBEHMT2 | |
| SCHEMBL17429741 | 0.77 | PDE3B (0.50) | POLB | |
| SCHEMBL1545308 | 0.77 | TLR8 (0.48) | POLBEHMT2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1309551-A1 | INDOLINE DERIVATIVES AS 5HT2C ANTAGONISTS | SMITHKLINE BEECHAM PLC (GB) | 2003-05-14 | — | — | EP | disclosed |
| WO-2002014273-A1 | INDOLINE DERIVATIVES AS 5HT2C ANTAGONISTS | SMITHKLINE BEECHAM P.L.C. (GB) | 2002-02-21 | — | — | WO | disclosed |