Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TYMP | P19971 | 4/20 | 0.53 |
| ▸ | GAA | P10253 | 2/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.50 |
| ▸ | PLA2G10 | O15496 | 1/20 | 0.50 |
| ▸ | HPGD | P15428 | 1/20 | 0.50 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.50 |
| ▸ | KIF11 | P52732 | 1/20 | 0.50 |
| ▸ | BACE1 | P56817 | 1/20 | 0.47 |
| ▸ | TNKS | O95271 | 1/20 | 0.46 |
| ▸ | WNT3A | P56704 | 1/20 | 0.46 |
| ▸ | TNKS2 | Q9H2K2 | 1/20 | 0.46 |
| ▸ | MAPK13 | O15264 | 1/20 | 0.44 |
| ▸ | RAF1 | P04049 | 1/20 | 0.44 |
| ▸ | MAPK12 | P53778 | 1/20 | 0.44 |
| ▸ | MAPK11 | Q15759 | 1/20 | 0.44 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.44 |
| ▸ | SCN2A | Q99250 | 2/20 | 0.42 |
| ▸ | MGAM | O43451 | 1/20 | 0.41 |
| ▸ | SI | P14410 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7094140 | 0.85 | ALDH1A1 (0.51) | TYMPGAAALDH1A1HPGDHSD17B10 | |
| SCHEMBL1572915 | 0.85 | ALDH1A1 (0.68) | TYMPGAAALDH1A1KDM4EPLA2G10 | |
| SCHEMBL30472340 | 0.81 | TNKS (0.55) | GAAKIF11BACE1TNKSWNT3A | |
| SCHEMBL29031843 | 0.81 | TNKS (0.55) | GAAKIF11BACE1TNKSWNT3A | |
| SCHEMBL8354646 | 0.80 | MAPK14 (0.53) | GAAALDH1A1KDM4EPLA2G10HPGD | |
| SCHEMBL1573566 | 0.80 | TYMP (0.62) | TYMPGAAALDH1A1KDM4EPLA2G10 | |
| SCHEMBL1573105 | 0.80 | KDM4E (0.55) | TYMPGAAALDH1A1KDM4EPLA2G10 | |
| SCHEMBL1573392 | 0.80 | TYMP (0.62) | TYMPGAAALDH1A1KDM4EPLA2G10 | |
| SCHEMBL1573106 | 0.76 | PTGS2 (0.50) | TYMPGAAALDH1A1KDM4EPLA2G10 | |
| SCHEMBL1573422 | 0.76 | KDM4E (0.50) | TYMPGAAALDH1A1KDM4EPLA2G10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2003084935-A2 | DIARYL PYRIMIDINONE DERIVATIVES USEFUL FOR THE TREATMENT OF INFLAMMATION AND IMMUNOGOLICAL DISEASES | ORCHID CHEMICALS & PHARMACEUTICALS LTD (IN) | 2003-10-16 | — | — | WO | claimed |
| WO-2003084935-A2 | DIARYL PYRIMIDINONE DERIVATIVES USEFUL FOR THE TREATMENT OF INFLAMMATION AND IMMUNOGOLICAL DISEASES | ORCHID CHEMICALS & PHARMACEUTICALS LTD (IN) | 2003-10-16 | — | — | WO | disclosed |